LOCUS       SIU02181.1               343 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            CONSERVED MEMBRANE PROTEIN protein.
ACCESSION   LT708304-3595
PROTEIN_ID  SIU02181.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3554"
                     /note="Mb3554, -, len: 343 aa. Equivalent to Rv3524, len:
                     343 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 343 aa overlap). Probable conserved
                     membrane protein, showing some similarity to C-terminal
                     part of putative Mycobacterium tuberculosis proteins
                     O05871|P95308|PKND_MYCTU|Rv0931c|MT0958|MTCY08C9.08
                     serine-threonine protein kinase PknD (EC 2.7.1.-) (664 aa)
                     FASTA scores: opt: 727, E(): 8.3e-36, (45.3% identity in
                     298 aa overlap); O53893|Rv0980c|MTV044.08c PGRS-FAMILY
                     PROTEIN (457 aa), FASTA scores: opt: 208, E(): 4.4e-05,
                     (33.75% identity in 166 aa overlap); and
                     O53891|Rv0978c|MTV044.06c PGRS-FAMILY PROTEIN (331 aa)
                     FASTA scores: opt: 153, E(): 0.062, (30.75% identity in
                     117 aa overlap). Contains PS00237 G-protein coupled
                     receptors signature. Protein product from Mb3554 detected
                     using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb3554 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y4G1"
                     /db_xref="InterPro:IPR001258"
                     /db_xref="InterPro:IPR013017"
                     /db_xref="InterPro:IPR035016"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y4G1"
BEGIN
        1 MVKFTPDSQT SVLRAGKCSG TLSPSRSRLQ RGSWPVDSER RRYGWPRNRR TLAITGAAVV
       61 VVVTLAAIGY LIFEPKISGS STSRQAASPT TPSPPSQVVV PIDLWNPDGV TVDLADAVYV
      121 ADSGHKRLLK LPAGSNTPTT LPFTDTIGPG GVAVNSNRDV YVIDEDSHHV LKLAAGIEPP
      181 VELPFGSLGD AHGLAVDRSD SVYVVDYDNA KVLKLPPGAD TPTELPFVGL DHPYDVAVDG
      241 AGTVYVTDSG HNRVVALTAG SATPVHLPFA DLSFPAGVTV DRDDSVYVAD LNNNRVLKLA
      301 AGSNAQSQLP FTGLFSPTDV AVDNDGAVYV IDFYNRMLKL PTA
//