LOCUS       SIU02179.1               354 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 possible
            lipid transfer protein or keto acyl-coa thiolase ltp4
            protein.
ACCESSION   LT708304-3593
PROTEIN_ID  SIU02179.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="ltp4"
                     /locus_tag="BQ2027_MB3552"
                     /note="Mb3552, -, len: 354 aa. Equivalent to Rv3522, len:
                     354 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.7% identity in 354 aa overlap). Possible lipid carrier
                     protein or keto acyl-CoA thiolase (EC 2.3.1.16), similar
                     to several e.g. O30103|AF0134 3-KETOACYL-COA THIOLASE
                     (ACAB-4) from Archaeoglobus fulgidus (398 aa) FASTA
                     scores: opt: 352, E(): 5.3e-15, (30.45% identity in 381 aa
                     overlap); O29295|AF0967 3-KETOACYL-COA THIOLASE (ACAB-9)
                     from Archaeoglobus fulgidus (400 aa) FASTA scores: opt:
                     312, E(): 1.8e-12, (28.05% identity in 367 aa overlap);
                     O29294|AF0968 3-KETOACYL-COA THIOLASE (ACAB-10) from
                     Archaeoglobus fulgidus (388 aa), FASTA scores: opt: 293,
                     E(): 2.9e-11, (25.9% identity in 309 aa overlap);
                     O58409|PH0676 LONG HYPOTHETICAL NONSPECIFIC LIPID-TRANSFER
                     PROTEIN (ACETHYL CoA SYNTHETASE) (EC 6.2.1.-) from
                     Pyrococcus horikoshii (389 aa), FASTA scores: opt: 292,
                     E(): 3.3e-11, (25.8% identity in 368 aa overlap);
                     Q9Y9A3|APE2382 LONG HYPOTHETICAL NON SPECIFIC
                     LIPID-TRANSFER PROTEIN from Aeropyrum pernix (360 aa)
                     FASTA scores: opt: 270, E(): 7.8e-10, (27.25% identity in
                     363 aa overlap); Q9YDI4|APE0929 LONG HYPOTHETICAL
                     NONSPECIFIC LIPID-TRANSFER PROTEIN from Aeropyrum pernix
                     (400 aa), FASTA scores: opt: 258, E(): 4.9e-09, (26.45%
                     identity in 306 aa overlap); etc. Contains PS00017
                     ATP/GTP-binding site motif A (P-loop). Protein product
                     from Mb3552 detected using shotgun mass spectrometry and
                     SWATH mass spectrometry. Mb3552 found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y4H2"
                     /db_xref="InterPro:IPR016039"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y4H2"
BEGIN
        1 MSVRDIAVVG FAHAPHVRRT DGTTNGVEML MPCFAQLYDE LGITKADIGF WCSGSSDYLA
       61 GRAFSFISAI DSIGAVPPIN ESHVEMDAAW ALYEAYIKLL TGEVDTALVY GFGKSSAGTL
      121 RRVLSRQTDP YTVAPLWPDS VSMAGLQARL GLDSGKWTHE QMARVAFDSF TNARRVDSVE
      181 PPITVGELLA RPFFADPLRR HDIAPITDGA AAVVLAADNR ARELRENPAW ITGIEHRIES
      241 PALGARDITE SPSTKLAAKI ATGGHTGDID VAEIHGPFTH QHLIVAEAIR IPGKTKVNPS
      301 GGPLAANPMF AAGLERIGFA AQHIWDGSAR RVLAHATSGP ALQQNLVAVM EGRG
//