LOCUS       SIU02133.1               393 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 pe
            family protein ppe60 protein.
ACCESSION   LT708304-3547
PROTEIN_ID  SIU02133.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="PPE60"
                     /locus_tag="BQ2027_MB3505"
                     /standard_name="mtb39c"
                     /note="Mb3505, PPE60, len: 393 aa. Equivalent to Rv3478,
                     len: 393 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 393 aa overlap). PPE60 (alternate gene
                     name: mtb39c). Member of the M. tuberculosis PPE family,
                     highly similar to others e.g.
                     Q11031|YD61_MYCTU|Rv1361c|MT1406|MTCY02B10.25c (396 aa),
                     FASTA scores: opt: 2165, E(): 1.1e-109, (85.35% identity
                     in 396 aa overlap); MTCI364.08; MTCY10G2.10; MTCY03A2.22c;
                     MTCY274.23c; MTCY164.34c; MTCY98.0029c; etc. Note that
                     expression of Rv3478 was demonstrated in lysates by
                     immunodetection (see citation below). Protein product from
                     Mb3505 detected using SWATH mass spectrometry. Mb3505
                     found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="InterPro:IPR000030"
                     /db_xref="InterPro:IPR022171"
                     /db_xref="InterPro:IPR038332"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y494"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MVDFGALPPE INSARMYAGP GSASLVAAAK MWDSVASDLF SAASAFQSVV WGLTVGSWIG
       61 SSAGLMAAAA SPYVAWMSVT AGQAQLTAAQ VRVAAAAYET AYRLTVPPPV IAENRTELMT
      121 LTATNLLGQN TPAIEANQAA YSQMWGQDAE AMYGYAATAA TATEALLPFE DAPLITNPGG
      181 LLEQAVAVEE AIDTAAANQL MNNVPQALQQ LAQPAQGVVP SSKLGGLWTA VSPHLSPLSN
      241 VSSIANNHMS MMGTGVSMTN TLHSMLKGLA PAAAQAVETA AENGVWAMSS LGSQLGSSLG
      301 SSGLGAGVAA NLGRAASVGS LSVPPAWAAA NQAVTPAARA LPLTSLTSAA QTAPGHMLGG
      361 LPLGHSVNAG SGINNALRVP ARAYAIPRTP AAG
//