LOCUS       SIU01974.1               112 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            SUCCINATE DEHYDROGENASE (CYTOCHROME B-556 SUBUNIT) SDHC
            (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE
            DEHYDROGENASE) (FUMARIC HYDROGENASE) protein.
ACCESSION   LT708304-3388
PROTEIN_ID  SIU01974.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="sdhC"
                     /locus_tag="BQ2027_MB3345"
                     /note="Mb3345, sdhC, len: 112 aa. Equivalent to Rv3316,
                     len: 112 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 112 aa overlap). Probable sdhC,
                     cytochrome B-556 of succinate dehydrogenase SdhC subunit
                     (EC 1.3.99.1), transmembrane protein, equivalent (but
                     shorter 35 aa) to Q9CCM0|SDHC|ML0699 PUTATIVE SUCCINATE
                     DEHYDROGENASE CYTOCHROME B-556 SUBUNIT from Mycobacterium
                     leprae (153 aa), FASTA scores: opt: 692, E(): 1.2e-39,
                     (88.4% identity in 112 aa overlap). Also similar to others
                     e.g. Q9KZ88|SC5G8.26c from Streptomyces coelicolor (126
                     aa), FASTA scores: opt: 484, E(): 8.3e-26, (65.65%
                     identity in 99 aa overlap); Q9RVR8|DR0954 from Deinococcus
                     radiodurans (118 aa), FASTA scores: opt: 195, E():
                     1.7e-06, (36.8% identity in 87 aa overlap);
                     Q9HQ63|DHSD_HALN1|SDHD|SDHC|VNG1310G from Halobacterium
                     sp. strain NRC-1 (130 aa), FASTA scores: opt: 192, E():
                     2.9e-06, (37.85% identity in 74 aa overlap);
                     P72109|DHSD_NATPH|SDHD|SDHC from Natronomonas pharaonis
                     (Natronobacterium pharaonis) (130 aa), FASTA scores: opt:
                     183, E(): 1.1e-05, (35.15% identity in 74 aa overlap);
                     etc. PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A
                     FLAVOPROTEIN, AN IRON-SULFUR, CYTOCHROME B-556, AND AN
                     HYDROPHOBIC ANCHOR PROTEIN. BELONGS TO THE CYTOCHROME B560
                     FAMILY. Protein product from Mb3345 detected using SWATH
                     mass spectrometry. Mb3345 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y3S5"
                     /db_xref="InterPro:IPR000701"
                     /db_xref="InterPro:IPR014314"
                     /db_xref="InterPro:IPR034804"
                     /db_xref="InterPro:IPR039023"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y3S5"
BEGIN
        1 MWSWVCHRIS GATIFFFLFV HVLDAAMLRV SPQTYNAVLA TYKTPIVGLM EYGLVAAVLF
       61 HALNGIRVIL IDFWSEGPRY QRLMLWIIGS VFLLLMVPAG VVVGIHMWEH FR
//