LOCUS       SIU01923.1               304 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 dtdp-
            6-deoxy-l-lyxo-4-hexulose reductase rmld (dtdp-rhamnose
            modification protein) (dtdp-rhamnose biosynthesis protein)
            (dtdp-rhamnose synthase) protein.
ACCESSION   LT708304-3337
PROTEIN_ID  SIU01923.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="rmlD"
                     /locus_tag="BQ2027_MB3294C"
                     /note="Mb3294c, rmld, len: 304 aa. Equivalent to Rv3266c,
                     len: 304 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.7% identity in 304 aa overlap). Possible rmld,
                     dTDP-rhamnose modification protein, highly similar to
                     Q9CCK8 putative dTDP-rhamnose modification protein from
                     Mycobacterium leprae (311 aa), FASTA scores, opt: 1440,
                     E(): 1.1e-78, (74.7% identity in 312 aa overlap); and
                     similar to several dtdp-4-dehydrorhamnose reductase (EC
                     1.1.1.133) e.g. STRL_STRGR|P29781 from Streptomyces
                     griseus (304 aa), FASTA scores, opt: 788, E(): 0, (47.4%
                     identity in 304 aa overlap). Protein product from Mb3294c
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb3294c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y3M5"
                     /db_xref="InterPro:IPR005913"
                     /db_xref="InterPro:IPR029903"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y3M5"
BEGIN
        1 MAGRSERLVI TGAGGQLGSH LTAQAAREGR DMLALTSSQW DITDPAAAER IIRHGDVVIN
       61 CAAYTDVDGA ESNEAVAYAV NATGPQHLAR ACARVGARLI HVSTDYVFDG DFGGAEPRPY
      121 EPTDETAPQG VYARSKLAGE QAVLAAFPEA AVVRTAWVYT GGTGKDFVAV MRRLAAGHGR
      181 VDVVDDQTGS PTYVADLAEA LLALADAGVR GRVLHAANEG VVSRFGQARA VFEECGADPQ
      241 RVRPVSSAQF PRPAPRPSYS ALSSRQWALA GLTPLRHWRS ALATALAAPA NSTSIDRRLP
      301 STRD
//