LOCUS       SIU01910.1               495 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE PROTEIN
            protein.
ACCESSION   LT708304-3324
PROTEIN_ID  SIU01910.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3281C"
                     /note="Mb3281c, -, len: 495 aa. Equivalent to Rv3253c,
                     len: 495 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 495 aa overlap). Possible cationic
                     amino acid transporter, integral membrane protein, similar
                     to many e.g. O69844|SC1C3.02 PUTATIVE CATIONIC AMINO ACID
                     TRANSPORTER from Streptomyces coelicolor (503 aa), FASTA
                     scores: opt: 1649, E(): 5.8e-92, (52.6% identity in 485 aa
                     overlap); Q9AE69 PUTATIVE TRANSPORTER (FRAGMENT) from
                     Rhodococcus erythropolis (385 aa), FASTA scores: opt:
                     1594, E(): 9.7e-89, (62.0% identity in 387 aa overlap);
                     Q9PBD7|XF2207 CATIONIC AMINO ACID TRANSPORTER from Xylella
                     fastidiosa (483 aa), FASTA scores: opt: 1079, E():
                     1.2e-57, (40.55% identity in 493 aa overlap);
                     Q9SRU9|F20H23.25 PUTATIVE CATIONIC AMINO ACID TRANSPORTER
                     from Arabidopsis thaliana (Mouse-ear cress) (614 aa),
                     FASTA scores: opt: 802, E(): 6.7e-41, (36.4% identity in
                     445 aa overlap); P30823|CTR1_RAT|SLC7A1|ATRC1
                     HIGH-AFFINITY CATIONIC AMINO ACID TRANSPORTER-1 from
                     Rattus norvegicus (Rat) (624 aa), FASTA scores: opt: 782,
                     E(): 1.1e-39, (36.1% identity in 432 aa overlap); etc.
                     Relatives in Mycobacterium tuberculosis include:
                     MTCY3G12.14, E(): 5.6e-31; MTCY39.19, E(): 1.6e-14. SEEMS
                     TO BELONG TO THE APC FAMILY. Mb3281c found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y3L9"
                     /db_xref="InterPro:IPR002293"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y3L9"
BEGIN
        1 MAGRRRMKSV EQSIADTDEP TTRLRKDLTW WDLVVFGVSV VIGAGIFTVT ASTAGDITGP
       61 AIWISFLIAA ATCALAALCY AEFASTLPVA GSAYTFSYAT FGEFLAWVIG WNLVLELAMG
      121 AAVVAKGWSS YLGTVFGFGN GTGHLGSLQL DWGALVIVTL VATLIALGTK LSSRFSAVVT
      181 AIKVSVVVLV VVVGAFYIRA ANYSPFIPEP EVQHHGGGLD QSVFSLLTGA QGSHYGWYGV
      241 LAGASIVFFA FIGFDIVATM AEETKRPQRD VPRGILASLG VVTLLYVAVS VVLSGMVPYT
      301 QLRTVPGRGP ANLATAFQAN GVYWASGIIS VGALAGLTTV VMVLMLGQCR VLFAMARDGL
      361 VPRQLAKTGS RGTPVRVTVL VAVLVATTAS VFPITKLEEM VNVGTLFAFI LVSAGVVVLR
      421 RTRPDLQRGF TAPWVPLLPI AAVCACLWLM LNLTALTWIR FGIWLVAGTA IYVGYGRRHS
      481 AQGLRQARES ATRRC
//