LOCUS       SIU01825.1               200 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR/ACRR-
            FAMILY) protein.
ACCESSION   LT708304-3239
PROTEIN_ID  SIU01825.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3198C"
                     /note="Mb3198c, -, len: 200 aa. Equivalent to Rv3173c,
                     len: 200 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 200 aa overlap). Probable
                     transcriptional regulatory protein tetR family, similar to
                     several bacterial putative regulatory proteins e.g.
                     Q9EWI2|SC7H9.14 from Streptomyces coelicolor (195 aa),
                     FASTA scores: opt: 319, E(): 1.7e-13, (34.55% identity in
                     195 aa overlap); O85695|3SCF60.04 from Streptomyces
                     lividans and Streptomyces coelicolor (192 aa), FASTA
                     scores: opt: 297, E(): 4.3e-12, (37.45% identity in 187 aa
                     overlap); BAB50853|MLR4117 from Rhizobium loti
                     (Mesorhizobium loti) (205 aa), FASTA scores: opt: 280,
                     E(): 5.5e-11, (31.45% identity in 194 aa overlap);
                     BAB53760|MLL8133 from Rhizobium loti (Mesorhizobium loti)
                     (194 aa), FASTA scores: opt: 270, E(): 2.3e-10, (34.05%
                     identity in 185 aa overlap); etc. Also similar to other
                     regulators from Mycobacterium tuberculosis e.g.
                     P96839|Rv3557c|MTCY06G11.04c (200 aa), FASTA scores: opt:
                     154, E(): 0.0013, (38.8% identity in 80 aa overlap).
                     Contains probable helix-turn-helix motif from aa 39 to 60
                     (Score 1251, +3.45 SD). SIMILAR TO THE TETR/ACRR FAMILY OF
                     TRANSCRIPTIONAL REGULATORS. Protein product from Mb3198c
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb3198c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y553"
                     /db_xref="InterPro:IPR001647"
                     /db_xref="InterPro:IPR009057"
                     /db_xref="InterPro:IPR036271"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y553"
BEGIN
        1 MPPVTRTTEP PRRGGRGARQ RILKAAAELF YCEGINATGV ELIANKASVS KRTLYQHFPS
       61 KSALVEEYLR GLRQAAGEAD KMPKASNATP RERLLALFDR PNRGDGRMRG CPFHNAAVEA
      121 AGEMPGVERI VHSHKRDYIK GLARLAREAG AAHPRSLGNQ LAVLFEGAAA LSTSLDDAGP
      181 WAHARAAAEV LIDQATARPV
//