LOCUS       SIU01792.1               323 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            NADPH QUINONE OXIDOREDUCTASE FADB4 (NADPH:QUINONE REDUCTASE)
            (ZETA-CRYSTALLIN) protein.
ACCESSION   LT708304-3206
PROTEIN_ID  SIU01792.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="fadB4"
                     /locus_tag="BQ2027_MB3165"
                     /note="Mb3165, fadB4, len: 323 aa. Equivalent to Rv3141,
                     len: 323 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 323 aa overlap). Probable fadB4,
                     quinone oxidoreductase (EC 1.6.5.5), showing strong
                     similarity to variety of quinone oxidoreductases and
                     domains in polyketide and fatty acid synthases e.g.
                     Q9HTV6|PA5234 PROBABLE OXIDOREDUCTASE from Pseudomonas
                     aeruginosa (325 aa), FASTA scores: opt: 737, E(): 1.4e-35,
                     (39.65% identity in 328 aa overlap); Q9RYQ7|DRA0251
                     PUTATIVE NADPH QUINONE OXIDOREDUCTASE from Deinococcus
                     radiodurans (336 aa), FASTA scores: opt: 688, E(): 1e-32,
                     (40.6% identity in 325 aa overlap); Q9RVG8|DR1061 PUTATIVE
                     NADPH QUINONE OXIDOREDUCTASE from Deinococcus radiodurans
                     (388 aa), FASTA scores: opt: 559, E(): 3.3e-25, (36.3%
                     identity in 325 aa overlap); BAB49685|MLL2594 PROBABLE
                     QUINONE OXIDOREDUCTASE from Rhizobium loti (Mesorhizobium
                     loti) (326 aa), FASTA scores: opt: 519, E(): 5.9e-23,
                     (34.25% identity in 330 aa overlap); Q9LXZ4|T5P19_110
                     QUINONE REDUCTASE-LIKE PROTEIN from Arabidopsis thaliana
                     (348 aa), FASTA scores: opt: 517, E(): 8.1e-23, (33.55%
                     identity in 322 aa overlap); etc. Also similar to
                     Q9AA38|CC0770 ZINC-CONTAINING ALCOHOL DEHYDROGENASE from
                     Caulobacter crescentus (325 aa), FASTA scores: opt: 673,
                     E(): 7.2e-32, (40.2% identity in 326 aa overlap); and
                     Q9ABX4|CC0096 ZINC-CONTAINING ALCOHOL DEHYDROGENASE from
                     Caulobacter crescentus (332 aa), FASTA scores: opt: 623,
                     E(): 5.7e-29, (40.7% identity in 334 aa overlap). Also
                     resembles Mycobacterium tuberculosis proteins
                     P96826|Rv0149|MTCI5_23, MTCY13D12.11, MTCY24G1.03,
                     MTCY19H9.01. BELONGS TO THE ZINC-CONTAINING ALCOHOL
                     DEHYDROGENASE FAMILY, QUINONE OXIDOREDUCTASE SUBFAMILY.
                     TBparse score is 0.904. Thought to be differentially
                     expressed within host cells (see first citation below).
                     Protein product from Mb3165 detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb3165 found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3Y374"
                     /db_xref="InterPro:IPR011032"
                     /db_xref="InterPro:IPR013149"
                     /db_xref="InterPro:IPR013154"
                     /db_xref="InterPro:IPR020843"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y374"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MRAVRVTRLE GPDAVEVAEV EEPTSAGVVI EVHAAGVAFP DALLTRGRYQ YRPEPPFVLG
       61 AEIAGVVRSA PDNSQVRSGD RVVGLTMLTG GMAEVAVLSP ERVFKLPDNM TFEAGAGVLF
      121 NDLTVYFALA VRGRLQAGET VLVHGAAGGI GTSTLRLAPA LGASRTVAVV STQEKAELAT
      181 VAGATDVVLA EGFKDAVQEL TNGRGVDIVV DPVGGDRFTD SLRSLAAGGR LLVIGFTGGE
      241 IPTVKVNRLL LNNIDVVGVG WGAWSLTHPD ALAQQWSQLE RLLRSGKLPP PEPVVYPLDQ
      301 AAAAIASLEN RTAKGKVVLR VRD
//