LOCUS       SIU01695.1               359 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            FEIII-DICITRATE-BINDING PERIPLASMIC LIPOPROTEIN FECB protein.
ACCESSION   LT708304-3109
PROTEIN_ID  SIU01695.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="fecB"
                     /locus_tag="BQ2027_MB3070"
                     /note="Mb3070, fecB, len: 359 aa. Equivalent to Rv3044,
                     len: 359 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 359 aa overlap). Probable fecB, FeIII
                     dicitrate-binding periplasmic lipoprotein (see citation
                     below), equivalent to Q9CBQ4|FECB|ML1729 PUTATIVE
                     FEIII-DICITRATE TRANSPORTER LIPOPROTEIN from Mycobacterium
                     leprae (364 aa), FASTA scores: opt: 1816, E(): 1.1e-96,
                     (75.65% identity in 357 aa overlap); and Q9LA57|FECB from
                     M. avium (364 aa), FASTA scores: opt: 1769, E(): 5.1e-94.
                     Similar to many periplasmic FeIII-dicitrate transporters
                     e.g. P72593|FECB|SLR1319 from Synechocystis sp. strain PCC
                     6803 (315 aa), FASTA scores: opt: 459, E(): 3.6e-19,
                     (31.35% identity in 303 aa overlap); and
                     P72611|FECB|SLR1492 from Synechocystis sp. strain PCC
                     6803. N-terminus longer (approximatively 30 aa) to
                     AAK47459 from Mycobacterium tuberculosis strain CDC1551
                     (327 aa). Has signal peptide and appropriately positioned
                     PS00013 Prokaryotic membrane lipoprotein lipid attachment
                     site. Protein product from Mb3070 detected using shotgun
                     mass spectrometry and SWATH mass spectrometry. Mb3070
                     found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="InterPro:IPR002491"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y4V9"
BEGIN
        1 MRSTVAVAVA AAVIAASSGC GSDQPAHKAS QSMITPTTQI AGAGVLGNDR KPDESCARAA
       61 AAADPGPPTR PAHNAAGVSP EMVQVPAEAQ RIVVLSGDQL DALCALGLQS RIVAAALPNS
      121 SSSQPSYLGT TVHDLPGVGT RSAPDLRAIA AAHPDLILGS QGLTPQLYPQ LAAIAPTVFT
      181 AAPGADWENN LRGVGAATAR IAAVDALITG FAEHATQVGT KHDATHFQAS IVQLTANTMR
      241 VYGANNFPAS VLSAVGVDRP PSQRFTDKAY IEIGTTAADL AKSPDFSAAD ADIVYLSCAS
      301 EAAAERAAVI LDSDPWRKLS ANRDNRVFVV NDQVWQTGEG MVAARGIVDD LRWVDAPIN
//