LOCUS       SIU01637.1               233 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            TRANSCRIPTIONAL REGULATORY PROTEIN protein.
ACCESSION   LT708304-3051
PROTEIN_ID  SIU01637.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3013"
                     /note="Mb3013, -, len: 233 aa. Equivalent to Rv2989, len:
                     233 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 233 aa overlap). Probable
                     transcriptional regulator (ala-rich protein), highly
                     similar to O86533|SC1C2.33c PUTATIVE TRANSCRIPTIONAL
                     REGULATOR from Streptomyces coelicolor (238 aa), FASTA
                     scores: opt: 711, E(): 2.3e-38, (53.05% identity in 230 aa
                     overlap); and similar to others e.g. Q9KND6 PUTATIVE
                     TRANSCRIPTIONAL REGULATOR from Vibrio cholerae (244 aa),
                     FASTA scores: opt: 232, E(): 1.2e-07, (29.75% identity in
                     232 aa overlap); Q9R9U0|SRPS EFFLUX PUMP REGULATOR from
                     Pseudomonas putida (259 aa), FASTA scores: opt: 224, E():
                     4.1e-07, (28.35% identity in 247 aa overlap); etc. Also
                     similar to proteins from Mycobacterium tuberculosis e.g.
                     O06806|Rv1773c|MTCY28.39 HYPOTHETICAL 26.6 KDA PROTEIN
                     (248 aa), FASTA scores: opt: 239, E(): 4.4e-08, (29.85%
                     identity in 231 aa overlap); P71977|RV1719|MTCY04C12.04
                     HYPOTHETICAL 27.9 KDA PROTEIN (259 aa), FASTA scores: opt:
                     215, E(): 1.6e-06, (31.85% identity in 223 aa overlap);
                     etc. Equivalent to AAK47396 from Mycobacterium
                     tuberculosis strain CDC1551 (267 aa) but shorter 34 aa.
                     Contains possible helix-turn-helix motif at aa 25-46
                     (Score 1005, +2.61 SD). Protein product from Mb3013
                     detected using shotgun mass spectrometry. Mb3013 found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y2Y6"
                     /db_xref="InterPro:IPR005471"
                     /db_xref="InterPro:IPR014757"
                     /db_xref="InterPro:IPR029016"
                     /db_xref="InterPro:IPR036388"
                     /db_xref="InterPro:IPR036390"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y2Y6"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MRQHSGIGVL DKAVGVLHAV AESPCGLAEL CDRTDLPRAT AYRLAAALEV HRLLGRGQDG
       61 HWRLGPAITE LATHVDDPLL VACAAVLPQL RDATGESVQV YRREGTSRVC VAALEPAAGL
      121 RDTVPVGARL PMTAGSGAKV LLAHTDAATQ AAVLPKAVFS ARALAEVCRR GWAQSVAERE
      181 PGVASVSAPV RDGRGVVIAA ISVSGPIDRM GRRPGVRWAA DLLSAADALT RRL
//