LOCUS       SIU01606.1               245 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            METHYLTRANSFERASE (METHYLASE) protein.
ACCESSION   LT708304-3020
PROTEIN_ID  SIU01606.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB2983C"
                     /note="Mb2983c, -, len: 245 aa. Equivalent to Rv2959c,
                     len: 245 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 245 aa overlap). Possible
                     methyltransferase (EC 2.1.1.-), highly similar to
                     Q9CD89|ML0127 from Mycobacterium leprae (229 aa), FASTA
                     scores: opt: 1183, E(): 3.9e-69, (76.1% identity in 226 aa
                     overlap). Also some similarity with other
                     methyltransferases and other proteins e.g. Q51079 PUTATIVE
                     METHYL TRANSFERASE from Nocardia lactamdurans (236 aa),
                     FASTA scores: opt: 156, E(): 0.0086, (23.25% identity in
                     159 aa overlap); Q98ID5 CEPHALOSPORIN HYDROXYLASE from
                     Rhizobium loti (Mesorhizobium loti) (217 aa), FASTA
                     scores: opt: 275, E(): 1.7e-10, (29.65% identity in 199 aa
                     overlap); etc. And also similar to P72897 HYPOTHETICAL
                     27.8 KDA PROTEIN from Mycobacterium tuberculosis (249 aa),
                     FASTA scores: opt: 292, E(): 1.5e-11, (31.25% identity in
                     208 aa overlap). Protein product from Mb2983c detected
                     using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb2983c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:Q7TXJ7"
                     /db_xref="InterPro:IPR007072"
                     /db_xref="InterPro:IPR029063"
                     /db_xref="UniProtKB/Swiss-Prot:Q7TXJ7"
BEGIN
        1 MGLVWRSRTS LVGQLIGLVR LVASFAAQLF YRPSDAVAEE YHKWYYGNLV WTKTTYMGIN
       61 CWKSVSDMWN YQEILSELQP SLVIEFGTRY GGSAVYFANI MRQIGQPFKV LTVDNSHKAL
      121 DPRARREPDV LFVESSSTDP AIAEQIQRLK NEYPGKIFAI LDSDHSMNHV LAEMKLLRPL
      181 LSAGDYLVVE DSNINGHPVL PGFGPGPYEA IEAYEDEFPN DYKHDAEREN KFGWTSAPNG
      241 FLIRN
//