LOCUS SIU01593.1 2112 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 probable polyketide synthase pks15 protein. ACCESSION LT708304-3007 PROTEIN_ID SIU01593.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="pks1" /locus_tag="BQ2027_MB2971C" /note="Mb2971c, pks1, len: 2112 aa. Equivalent to Rv2947c and Rv2946c, len: 496 aa and 1616 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 488 aa overlap and 99.9% identity in 1616 aa overlap). Rv2947c: Probable pks15, polyketide synthase. Almost identical to G560508|Q50469 PKS002B protein from Mycobacterium tuberculosis (495 aa), FASTA scores: opt: 3270, E(): 0, (99.6% identity in 496 a a overlap). Similar to Mycobacterium tuberculosis proteins MTCY338.20|RV2931|PPSA_MYCTU ppsA phenolpthiocerol synthesis (1876 aa) (49.9% identity in 465 aa overlap); MTCY24G1.09|RV2940C|P96291 Putative mas, mycocerosic acid synthase (2111 aa) (50.2% identity in 454 aa overlap); and MTCY22H8.03|RV2382C|P71718 hypothetical protein (444 aa) (47.6% identity in 437 aa overlap). Contains PS00606 Beta-ketoacyl synthases active site. Rv2946c: Probable pks1, polyketide synthase, similar to many e.g. ML035|AL583917|Q9CD81 putative polyketide synthase from Mycobacterium leprae (2103 aa), Fasta scores: opt: 8761, E(): 0, (82.6% identity in 1620 aa overlap); etc. Almost identical in part to G560507|Q50470 PKS002C protein from Mycobacterium tuberculosis (fragment) (950 aa), Fasta scores: opt: 5685, E(): 0, (95.3% identity in 927 aa overlap). Also similar to Mycobacterium tuberculosis polyketide synthases pks7|Rv1661|P94996 (2126 aa) (54.6% identity in 1632 aa); pks12|Rv2048c|O53490 (4151 aa) (58.0% identity in 1606 aa); pks8|rv1662|O65933 (1602 aa) (59.7% identity in 1144 aa). Contains a PS00012 Phosphopantetheine attachment site. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis H37Rv, pks1 and pks15 exist as 2 genes. In Mycobacterium bovis, a single base insertion (*-g) results in a single product that is more similar to pks1. Protein product from Mb2971c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb2971c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:Q7TXK8" /db_xref="InterPro:IPR001227" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR013968" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR015083" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020801" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020807" /db_xref="InterPro:IPR020841" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR032821" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036299" /db_xref="InterPro:IPR036736" /db_xref="InterPro:IPR042104" /db_xref="UniProtKB/Swiss-Prot:Q7TXK8" BEGIN 1 MIEEQRTMSV EGADQQSEKL FHYLKKVAVE LDETRARLRE YEQRATEPVA VVGIGCRFPG 61 GVDGPDGLWD VVSAGRDVVS EFPTDRGWDV EGLYDPDPDA EGKTYTRWGA FLDDATGFDA 121 GFFGIAPSEV LAMDPQQRLM LEVSWEALEH AGIDPLSLRG SATGVYTGIF AASYGNRDTG 181 GLQGYGLTGT SISVASGRVS YVLGLQGPAV SVDTACSSSL VAIHWAMSSL RSGECDLALA 241 GGVTVMGLPS IFVGFSRQRG LAADGRCKAF AAAADGTGWG EGAGVVVLER LSDARRLGHS 301 VLAVVRGSAV NQDGASNGLT APNGLAQQRV IQAALANAGL SAADVDVVEA HGTATTLGDP 361 IEAQALLSTY GQGRPAEQPL WVGSIKSNMG HTQAAAGVAG VIKMVQAMRH GVMPATLHVD 421 EPSPRVDWTS GAVSVLTEAR EWSVDGRPRR AAVSSFGISG TNAHLILEEA PVPAPAEAPV 481 EASESTGGPR PSMVPWVISA RSAEALTAQA GRLMAHVQAN PGLDPIDVGC SLASRSVFEH 541 RAVVVGASRE QLIAGLAGLA AGEPGAGVAV GQPGSVGKTV VVFPGQGAQR IGMGRELYGE 601 LPVFAQAFDA VADELDRHLR LPLRDVIWGA DADLLDSTEF AQPALFAVEV ASFAVLRDWG 661 VLPDFVMGHS VGELAAAHAA GVLTLADAAM LVVARGRLMQ ALPAGGAMVA VAASEDEVEP 721 LLGEGVGIAA INAPESVVIS GAQAAANAIA DRFAAQGRRV HQLAVSHAFH SPLMEPMLEE 781 FARVAARVQA REPQLGLVSN VTGELAGPDF GSAQYWVDHV RRPVRFADSA RHLQTLGATH 841 FIEAGPGSGL TGSIEQSLAP AEAMVVSMLG KDRPELASAL GAAGQVFTTG VPVQWSAVFA 901 GSGGRRVQLP TYAFQRRRFW ETPGADGPAD AAGLGLGATE HALLGAVVER PDSDEVVLTG 961 RLSLADQPWL ADHVVNGVVL FPGAGFVELV IRAGDEVGCA LIEELVLAAP LVMHPGVGVQ 1021 VQVVVGAADE SGHRAVSVYS RGDQSQGWLL NAEGMLGVAA AETPMDLSVW PPEGAESVDI 1081 SDGYAQLAER GYAYGPAFQG LVAIWRRGSE LFAEVVAPGE AGVAVDRMGM HPAVLDAVLH 1141 ALGLAVEKTQ ASTETRLPFC WRGVSLHAGG AGRVRARFAS AGADAISVDV CDATGLPVLT 1201 VRSLVTRPIT AEQLRAAVTA AGGASDQGPL EVVWSPISVV SGGANGSAPP APVSWADFCA 1261 GSDGDASVVV WELESAGGQA SSVVGSVYAA THTALEVLQS WLGADRAATL VVLTHGGVGL 1321 AGEDISDLAA AAVWGMARSA QAENPGRIVL IDTDAAVDAS VLAGVGEPQL LVRGGTVHAP 1381 RLSPAPALLA LPAAESAWRL AAGGGGTLED LVIQPCPEVQ APLQAGQVRV AVAAVGVNFR 1441 DVVAALGMYP GQAPPLGAEG AGVVLETGPE VTDLAVGDAV MGFLGGAGPL AVVDQQLVTR 1501 VPQGWSFAQA AAVPVVFLTA WYGLADLAEI KAGESVLIHA GTGGVGMAAV QLARQWGVEV 1561 FVTASRGKWD TLRAMGFDDD HIGDSRTCEF EEKFLAVTEG RGVDVVLDSL AGEFVDASLR 1621 LLVRGGRFLE MGKTDIRDAQ EIAANYPGVQ YRAFDLSEAG PARMQEMLAE VRELFDTREL 1681 HRLPVTTWDV RCAPAAFRFM SQARHIGKVV LTMPSALADR LADGTVVITG ATGAVGGVLA 1741 RHLVGAYGVR HLVLASRRGD RAEGAAELAA DLTEAGAKGQ VVACDVADRA AVAGLFAQLS 1801 REYPPVRGVI HAAGVLDDAV ITSLTPDRID TVLRAKVDAA WNLHQATSDL DLSMFVLCSS 1861 IAATVGSPGQ GNYSAANAFL DGLAAHRQAA GLAGISLAWG LWEQPGGMTA HLSSRDLARM 1921 SRSGLAPMSP AEAVELFDAA LAIDHPLAVA TLLDRAALDA RAQAGALPAL FSGLARRPRR 1981 RQIDDTGDAT SSKSALAQRL HGLAADEQLE LLVGLVCLQA AAVLGRPSAE DVDPDTEFGD 2041 LGFDSLTAVE LRNRLKTATG LTLPPTVIFD HPTPTAVAEY VAQQMSGSRP TESGDPTSQV 2101 VEPAAAEVSV HA //