LOCUS       SIU01583.1               289 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 daunorubicin-
            dim-transport integral membrane protein abc transporter
            drrb protein.
ACCESSION   LT708304-2997
PROTEIN_ID  SIU01583.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="drrB"
                     /locus_tag="BQ2027_MB2962"
                     /note="Mb2962, drrB, len: 289 aa. Equivalent to Rv2937,
                     len: 289 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 289 aa overlap). Probable drrB,
                     daunorubicin-DIM-transport integral membrane protein ABC
                     transporter, probably involved in daunorubicin resistance
                     and phthiocerol dimycocerosate transport (see citations
                     below), equivalent to Q49935|DRRB|ML2351|L518_F1_9
                     DAUNORUBICIN RESISTANCE TRANSMEMBRANE PROTEIN from
                     Mycobacterium leprae (288 aa), FASTA scores: opt: 1252,
                     E(): 5.3e-72, (64.0% identity in 289 aa overlap). Also
                     similar to others e.g. Q9XCF8 DRRB PROTEIN from
                     Mycobacterium avium (246 aa), FASTA scores: opt: 423, E():
                     1.5e-19, (30.85% identity in 243 aa overlap); Q9S6H4
                     DAUNORUBICIN RESISTANCE PROTEIN B from Mycobacterium avium
                     (246 aa), FASTA scores: opt: 420, E(): 2.3e-19, (30.85%
                     identity in 243 aa overlap); P32011|DRRB_STRPE
                     DAUNORUBICIN RESISTANCE TRANSMEMBRANE PROTEIN from
                     Streptomyces peucetius (283 aa), FASTA scores: opt: 242,
                     E(): 4.7e-08, (27.85% identity in 219 aa overlap); etc.
                     Note that Rv293|drrB belongs to the transcriptional unit
                     Rv2930|fadD26-Rv2939|papA5 (proven experimentaly). Protein
                     product from Mb2962 detected using SWATH mass
                     spectrometry. Mb2962 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y2N5"
                     /db_xref="InterPro:IPR000412"
                     /db_xref="InterPro:IPR004377"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y2N5"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MSGPAIDASP ALTFNQSSAS IQQRRLSTGR QMWVLYRRFA APSLLNGEVL TTVGAPIIFM
       61 VGFYIPFAIP WNQFVGGASS GVASNLGQYI TPLVTLQAVS FAAIGSGFRA ATDSLLGVNR
      121 RFQSMPMAPL TPLLARVWVA VDRCFTGLVI SLVCGYVIGF RFHRGALYIV GFCLLVIAIG
      181 AVLSFAADLV GTVTRNPDAM LPLLSLPILI FGLLSIGLMP LKLFPHWIHP FVRNQPISQF
      241 VAALRALAGD TTKTASQVSW PVMAPTLTWL FAFVVILALS STIVLARRP
//