LOCUS       SIU01548.1               294 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            SIGNAL PEPTIDASE I LEPB (SPASE I) (LEADER PEPTIDASE I)
            . protein.
ACCESSION   LT708304-2962
PROTEIN_ID  SIU01548.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="lepB"
                     /locus_tag="BQ2027_MB2927C"
                     /note="Mb2927c, lepB, len: 294 aa. Equivalent to Rv2903c,
                     len: 294 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.7% identity in 294 aa overlap). Probable lepB, signal
                     peptidase I (EC 3.4.21.89) (TYPE II MEMBRANE PROTEIN) (see
                     first citation below), equivalent to
                     O33021|LEP_MYCLE|ML1612|MLCB250.39 PROBABLE SIGNAL
                     PEPTIDASE I from Mycobacterium leprae (289 aa), FASTA
                     scores: opt: 1335, E(): 1.8e-77, (69.75% identity in 301
                     aa overlap). Also similar to many e.g. O86869|SIPX SIGNAL
                     PEPTIDASE I from Streptomyces lividans (320 aa), FASTA
                     scores: opt: 474, E(): 1e-22, (43.55% identity in 248 aa
                     overlap); O69884|SIP1|SIPW PUTATIVE SIGNAL PEPTIDASE I
                     from Streptomyces coelicolor and Streptomyces lividans
                     (259 aa), FASTA scores: opt: 226, E(): 5e-07, (36.0%
                     identity in 214 aa overlap); P42668|LEP_BACLI|SIP SIGNAL
                     PEPTIDASE I from Bacillus licheniformis (186 aa), FASTA
                     scores: opt: 218, E(): 1.3e-06, (34.5% identity in 194 aa
                     overlap); etc. Contains PS00501 Signal peptidases I serine
                     active site,and PS00761 Signal peptidases I signature 3.
                     BELONGS TO PEPTIDASE FAMILY S26; ALSO KNOWN AS TYPE I
                     LEADER PEPTIDASE FAMILY. Protein product from Mb2927c
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb2927c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y2Y2"
                     /db_xref="InterPro:IPR000223"
                     /db_xref="InterPro:IPR015927"
                     /db_xref="InterPro:IPR019533"
                     /db_xref="InterPro:IPR019756"
                     /db_xref="InterPro:IPR019758"
                     /db_xref="InterPro:IPR036286"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y2Y2"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MTETTDSPSE RQPGPAEPEL SSRDPDIAGQ VFDAAPFDAA PDADSEGDSK AAKTDEPRPA
       61 KRSTLREFAV LAVIAVVLYY VMLTFVARPY LIPSESMEPT LHGCSTCVGD RIMVDKLSYR
      121 FGSPQPGDVI VFRGPPSWNV GYKSIRSHNV AVRWVQNALS FIGFVPPDEN DLVKRVIAVG
      181 GQTVQCRSDT GLTVNGRPLK EPYLDPATMM ADPSIYPCLG SEFGPVTVPP GRVWVMGDNR
      241 THSADSRAHC PLLCTNDPLP GTVPVANVIG KARLIVWPPS RWGVVRSVNP QQGR
//