LOCUS       SIU01547.1               264 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            RIBONUCLEASE HII PROTEIN RNHB (RNASE HII) protein.
ACCESSION   LT708304-2961
PROTEIN_ID  SIU01547.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="rnhB"
                     /locus_tag="BQ2027_MB2926C"
                     /note="Mb2926c, rnhB, len: 264 aa. Equivalent to Rv2902c,
                     len: 264 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.6% identity in 264 aa overlap). Probable rnhB,
                     ribonuclease HII (EC 3.1.26.4), equivalent to
                     O33022|RNH2_MYCLE|RNHB|ML1611|MLCB250.40 RIBONUCLEASE HII
                     from Mycobacterium leprae (240 aa), FASTA scores: opt:
                     1242, E(): 6.9e-72, (76.75% identity in 245 aa overlap).
                     Also similar (but longer ~20 aa) to others e.g.
                     Q9HXY9|RNHB|PA3642 RIBONUCLEASE HII from Pseudomonas
                     aeruginosa (201 aa), FASTA scores: opt: 572, E(): 3.1e-29,
                     (52.7% identity in 184 aa overlap);
                     Q9PEI7|RNH2_XYLFA|RNHB|XF1041 RIBONUCLEASE HII from
                     Xylella fastidiosa (234 aa), FASTA scores: opt: 556, E():
                     3.6e-28, (50.25% identity in 185 aa overlap);
                     P10442|RNH2_ECOLI|RNHB|B0183 RIBONUCLEASE HII from
                     Escherichia coli strain K-12 (213 aa), FASTA scores: opt:
                     519, E(): 7.4e-26, (48.65% identity in 183 aa overlap);
                     etc. BELONGS TO THE RNASE HII FAMILY. COFACTOR: MANGANESE
                     (BY SIMILARITY). Protein product from Mb2926c detected
                     using SWATH mass spectrometry. Mb2926c found to be
                     expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:Q7TXM7"
                     /db_xref="InterPro:IPR001352"
                     /db_xref="InterPro:IPR012337"
                     /db_xref="InterPro:IPR022898"
                     /db_xref="InterPro:IPR024567"
                     /db_xref="InterPro:IPR036397"
                     /db_xref="UniProtKB/Swiss-Prot:Q7TXM7"
BEGIN
        1 MTKTWPPRTV IRKSGGLRGM RTLESALHRG GLGPVAGVDE VGRGACAGPL VVAACVLGPG
       61 RIASLAALDD SKKLSEQARE KLFPLICRYA VAYHVVFIPS AEVDRHGVHV ANIEGMRRAV
      121 AGLAVRPGYV LSDGFRVPGL PMPSLPVIGG DAAAACIAAA SVLAKVSRDR VMVALDADHP
      181 GYGFAEHKGY STPAHSRALA RLGPCPQHRY SFINVRRVAS GSNTAEVADG QPDPRDGTAQ
      241 TGEGRWSKSS HPATMRATGR AQGT
//