LOCUS       SIU01261.1               316 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            acyltransferase protein.
ACCESSION   LT708304-2675
PROTEIN_ID  SIU01261.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB2643C"
                     /note="Mb2643c, -, len: 316 aa. Equivalent to Rv2611c,
                     len: 316 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.4% identity in 316 aa overlap). Probable
                     acyltransferase (EC 2.3.1.-), equivalent to
                     O07148|MLCL581.15c|ML0453 HYPOTHETICAL 35.4 KDA PROTEIN
                     from Mycobacterium leprae (320 aa), FASTA scores: opt:
                     1529, E(): 5e-90, (71.45% identity in 312 aa overlap); and
                     equivalent to Q9F7Y8 PUTATIVE ACYLTRANSFERASE from
                     Mycobacterium smegmatis (303 aa), FASTA scores: opt: 1464,
                     E(): 6.5e-86, (72.15% identity in 291 aa overlap) (see
                     citation below). Also highly similar to Q9L283|SCL2.16c
                     PUTATIVE ACYLTRANSFERASE from Streptomyces coelicolor (311
                     aa), FASTA scores: opt: 810, E(): 2.8e-44, (47.7% identity
                     in 302 aa overlap); and similar to other acyltransferases
                     e.g. Q9F0N3 ACYLTRANSFERASE from Campylobacter jejuni (295
                     aa), FASTA scores: opt: 207, E(): 6.4e-06, (20.45%
                     identity in 220 aa overlap); Q9K379 ACYLTRANSFERASE (LIPID
                     A BIOSYNTHESIS ACYLTRANSFERASE) from Campylobacter jejuni
                     (295 aa), FASTA scores: opt: 203, E(): 1.1e-05, (20.0%
                     identity in 220 aa overlap); etc. Protein product from
                     Mb2643c detected using SWATH mass spectrometry. Mb2643c
                     found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3Y1Q0"
                     /db_xref="InterPro:IPR004960"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y1Q0"
BEGIN
        1 MIAGLKGLKL PKDPRSSVTR TATDWAYAAG WMAVRALPEF AVRNAFDTGA RYFARHGGPE
       61 QLRKNLARVL GVPPAAVPDP LMCASLESYG RYWREVFRLP TMNHRKLARQ LDRVIGGLDH
      121 LDAALAAGLG AVLALPHSGN WDMAGMWLVQ RHGTFTTVAE RLKPESLYQR FIDYRESLGF
      181 EVLPLSGGER PPFEVLCERL RNNRVVCLMA ERDLTRTGVE VDFFGEPTRM PVGPAKLAVE
      241 TGAALLPTHC WFEGRGWGFQ VYPALDCTSG DVAAITQALA DRFAQNIAAH PADWHMLQPQ
      301 WLADLSESRR AQLRSR
//