LOCUS       SIU01238.1               449 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 4-AMINOBUTYRATE
            AMINOTRANSFERASE GABT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE)
            (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEMIALDEHYDE TRANSAMINASE)
            (GABA AMINOTRANSFERASE) (GABA-AT) protein.
ACCESSION   LT708304-2652
PROTEIN_ID  SIU01238.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="gabT"
                     /locus_tag="BQ2027_MB2620"
                     /note="Mb2620, gabT, len: 449 aa. Equivalent to Rv2589,
                     len: 449 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 449 aa overlap). Probable gabT,
                     4-aminobutyrate aminotransferase (EC 2.6.1.9), equivalent
                     to P40829|GABT_MYCLE|ML0485|MLCB1259.03c|B1177_F2_67
                     4-AMINOBUTYRATE AMINOTRANSFERASE (446 aa), FASTA scores:
                     opt: 2468, E(): 4.5e-141, (83.75% identity in 449 aa
                     overlap). Also highly similar to others e.g. O86823|GABT
                     from Streptomyces coelicolor (444 aa), FASTA scores: opt:
                     1832, E(): 8e-103, (63.9% identity in 443 aa overlap);
                     AAK79395|CAC1427 from Clostridium acetobutylicum (445 aa),
                     FASTA scores: opt: 1283, E(): 8.4e-70, (45.75% identity in
                     433 aa overlap); Q9KE66|BH0991 from Bacillus halodurans
                     (443 aa), FASTA scores: opt: 1224, E(): 2.9e-66, (44.55%
                     identity in 431 aa overlap); etc. Contains PS00600
                     Aminotransferases class-III pyridoxal-phosphate attachment
                     site. BELONGS TO CLASS-III OF
                     PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. COFACTOR:
                     PYRIDOXAL PHOSPHATE. Protein product from Mb2620 detected
                     using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb2620 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P63505"
                     /db_xref="InterPro:IPR004632"
                     /db_xref="InterPro:IPR005814"
                     /db_xref="InterPro:IPR015421"
                     /db_xref="InterPro:IPR015422"
                     /db_xref="InterPro:IPR015424"
                     /db_xref="UniProtKB/Swiss-Prot:P63505"
BEGIN
        1 MASLQQSRRL VTEIPGPASQ ALTHRRAAAV SSGVGVTLPV FVARAGGGIV EDVDGNRLID
       61 LGSGIAVTTI GNSSPRVVDA VRTQVAEFTH TCFMVTPYEG YVAVAEQLNR ITPGSGPKRS
      121 VLFNSGAEAV ENAVKIARSY TGKPAVVAFD HAYHGRTNLT MALTAKSMPY KSGFGPFAPE
      181 IYRAPLSYPY RDGLLDKQLA TNGELAAARA IGVIDKQVGA NNLAALVIEP IQGEGGFIVP
      241 AEGFLPALLD WCRKNHVVFI ADEVQTGFAR TGAMFACEHE GPDGLEPDLI CTAKGIADGL
      301 PLSAVTGRAE IMNAPHVGGL GGTFGGNPVA CAAALATIAT IESDGLIERA RQIERLVTDR
      361 LTTLQAVDDR IGDVRGRGAM IAVELVKSGT TEPDAGLTER LATAAHAAGV IILTCGMFGN
      421 IIRLLPPLTI GDELLSEGLD IVCAILADL
//