LOCUS       SIU01177.1               947 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            AMINO ACID DECARBOXYLASE protein.
ACCESSION   LT708304-2591
PROTEIN_ID  SIU01177.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB2560C"
                     /note="Mb2560c, -, len: 947 aa. Equivalent to Rv2531c,
                     len: 947 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 947 aa overlap). Probable amino acid
                     decarboxylase (EC 4.1.1.-), equivalent to
                     Q9CCR8|ADI|ML0524 PUTATIVE AMINO ACID DECARBOXYLASE from
                     Mycobacterium leprae (950 aa), FASTA scores: opt: 5426,
                     E(): 0, (86.45% identity in 951 aa overlap). Also similar
                     to other amino acid decarboxylases (but longer in
                     N-terminus) e.g. Q9I2S7|PA1818 PROBABLE ORN/ARG/LYS AMINO
                     ACID DECARBOXYLASE from Pseudomonas aeruginosa (751 aa),
                     FASTA scores: opt: 434, E(): 2.5e-19, (29.15% identity in
                     738 aa overlap); Q9CML3|SPEF|PM0806 ORNITHINE
                     DECARBOXYLASE from Pasteurella multocida (720 aa), FASTA
                     scores: opt: 402, E(): 2.4e-17, (24.85% identity in 752 aa
                     overlap); P21169|DCOR_ECOLI|SPEC|B2965|BAB37264|ECS3841|AA
                     G58096 ORNITHINE DECARBOXYLASE ISOZYME (CONSTITUTIVE
                     ENZYME) from Escherichia coli strain K12 (711 aa), FASTA
                     scores: opt: 396, E(): 5.6e-17, (28.0% identity in 646 aa
                     overlap); P44317|DCOR_HAEIN|SPEF|HI0591 ORNITHINE
                     DECARBOXYLASE from Haemophilus influenzae (720 aa), FASTA
                     scores: opt: 393, E(): 8.8e-17, (25.05% identity in 743 aa
                     overlap); etc. SEEMS TO BELONG TO FAMILY 1 OF ORNITHINE,
                     LYSINE, AND ARGININE DECARBOXYLASES. Note that previously
                     known as adi. Protein product from Mb2560c detected using
                     shotgun mass spectrometry and SWATH mass spectrometry.
                     Mb2560c found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3Y1Q3"
                     /db_xref="InterPro:IPR000310"
                     /db_xref="InterPro:IPR008286"
                     /db_xref="InterPro:IPR015424"
                     /db_xref="InterPro:IPR036633"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y1Q3"
BEGIN
        1 MNPNSVRPRR LHVSALAAVA NPSYTRLDTW NLLDDACRHL AEVDLAGLDT THDVARAKRL
       61 MDRIGAYERY WLYPGAQNLA TFRAHLDSHS TVRLTEEVSL AVRLLSEYGD RTALFDTSAS
      121 LAEQELVAQA KQQQFYTVLL ADDSPATAPD SLAECLRQLR NPADEVQFEL LVVASIEDAI
      181 TAVALNGEIQ AAIIRHDLPL RSRDRVPLMT TLLGTDGDEA VANETHDWVE CAEWIRELRP
      241 HIDLYLLTDE SIAAETQDEP DVYDRTFYRL NDVTDLHSTV LAGLRNRYAT PFFDALRAYA
      301 AAPVGQFHAL PVARGASIFN SKSLHDMGEF YGRNIFMAET STTSGGLDSL LDPHGNIKTA
      361 MDKAAVTWNA NQTYFVTNGT STANKIVVQA LTRPGDIVLI DRNCHKSHHY GLVLAGAYPM
      421 YLDAYPLPQY AIYGAVPLRT IKQALLDLEA AGQLHRVRML LLTNCTFDGV VYNPRRVMEE
      481 VLAIKPDICF LWDEAWYAFA TAVPWARQRT AMIAAERLEQ MLSTAEYAEE YRNWCASMDG
      541 VDRSEWVDHR LLPDPNRARV RVYATHSTHK SLSALRQASM IHVRDQDFKA LTRDAFGEAF
      601 LTHTSTSPNQ QLLASLDLAR RQVDIEGFEL VRHVYNMALV FRHRVRKDRL ISKWFRILDE
      661 SDLVPDAFRS STVSSYRQVR QGALADWNEA WRSDQFVLDP TRLTLFIGAT GMNGYDFREK
      721 ILMERFGIQI NKTSINSVLL IFTIGVTWSS VHYLLDVLRR VAIDLDRSQK AASGADLALH
      781 RRHVEEITQD LPHLPDFSEF DLAFRPDDAS SFGDMRSAFY AGYEEADREY VQIGLAGRRL
      841 AEGKTLVSTT FVVPYPPGFP VLVPGQLVSK EIIYFLAQLD VKEIHGYNPD LGLSVFTQAA
      901 LARMEAARNA VATVGAALPA FEVPRDASAL NGTVNGDSVL QGVAEDA
//