LOCUS       SIU00999.1               435 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            CONSERVED TRANSMEMBRANE PROTEIN protein.
ACCESSION   LT708304-2413
PROTEIN_ID  SIU00999.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB2387C"
                     /note="Mb2387c, -, len: 435 aa. Equivalent to Rv2366c,
                     len: 435 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 435 aa overlap). Probable conserved
                     transmembrane protein, highly similar to Q9L2L3|SCC117.07
                     PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor
                     (358 aa), FASTA scores: opt: 1159, E(): 5.5e-64, (53.0%
                     identity in 353 aa overlap); ans similar to hypothetical
                     proteins and hemolysin-related proteins e.g.
                     Q9HN02|HLP|VNG2308G HEMOLYSIN PROTEIN from Halobacterium
                     sp. strain NRC-1 (457 aa), FASTA scores: opt: 623, E():
                     6.2e-31, (28.4% identity in 433 aa overlap); etc.
                     Potential transmembrane protein with 2 CBS domains.
                     BELONGS TO THE UPF0053 FAMILY. Protein product from
                     Mb2387c detected using shotgun mass spectrometry and SWATH
                     mass spectrometry. Mb2387c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P67131"
                     /db_xref="InterPro:IPR000644"
                     /db_xref="InterPro:IPR002550"
                     /db_xref="InterPro:IPR005170"
                     /db_xref="InterPro:IPR016169"
                     /db_xref="InterPro:IPR036318"
                     /db_xref="UniProtKB/Swiss-Prot:P67131"
BEGIN
        1 MTGYYQLLGS IVLIGLGGLF AAIDAAISTV SPARVDELVR DQRPGAGSLR KVMADRPRYV
       61 NLVVLLRTSC EITATALLVV FIRYHFSMVW GLYLAAGIMV LASFVVVGVG PRTLGRQNAY
      121 SISLATALPL RLISWLLMPI SRLLVLLGNA LTPGRGFRNG PFASEIELRE VVDLAQQRGV
      181 VAADERRMIE SVFELGDTPA REVMVPRTEM IWIESDKTAG QAMTLAVRSG HSRIPVIGEN
      241 VDDIVGVVYL KDLVEQTFCS TNGGRETTVA RVMRPAVFVP DSKPLDALLR EMQRDRNHMA
      301 LLVDEYGAIA GLVSIEDVLE EIVGEIADEY DQAETAPVED LGDKRFRVSA RLPIEDVGEL
      361 YGVEFDDDLD VDTVGGLLAL ELGRVPLPGA EVISHGLRLH AEGGTDHRGR VRIGTVLLSP
      421 AEPDGADDEE ADHPG
//