LOCUS       SIU00988.1               457 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PPE
            FAMILY PROTEIN protein.
ACCESSION   LT708304-2402
PROTEIN_ID  SIU00988.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="PPE71"
                     /locus_tag="BQ2027_MB2376C"
                     /note="Mb2376c, PPE71, len: 457 aa. Equivalent to 5' end
                     of MT2423, len: 621 aa, from Mycobacterium tuberculosis
                     strain CDC1551, (98.475% identity in 459 aa overlap). PPE
                     FAMILY PROTEIN. REMARK-M.bovis-M.tuberculosis: In
                     Mycobacterium bovis, there is a large 8963 bp deletion
                     (RD5) in between Mb2375c and Mb2377c compared to
                     Mycobacterium tuberculosis strain H37Rv. In this region of
                     Mycobacterium bovis two substitutions are present that
                     encode a CDS, Mb2376c, equivalent to that found in
                     Mycobacterium tuberculosis strain CDC1551. The first
                     substitution is of 1218 bp to 350 bp and the second is of
                     123 bp to 431 bp. Mb2376c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="InterPro:IPR000030"
                     /db_xref="InterPro:IPR002989"
                     /db_xref="InterPro:IPR038332"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y0W9"
BEGIN
        1 MVNFSVLPPE INSGRMFFGA GSGPMLAAAA AWDGLAAELG LAAESFGLVT SGLAGGSGQA
       61 WQGAAAAMVV AAAPYAGWLA AAAARAGGAA VQAKAVAGAF EAARAAMVDP VVVAANRSAF
      121 VQLVLSNVFG QNAPAIAAAE ATYEQMWAAD VAAMVGYHGG ASAAAALAPW QQAVPGLLGL
      181 LDSAQSSAQA VTAQAVGSTV PGPLQGINFG FGNIGSLNLG SGNTGDTNVG SGNIGNTNLG
      241 GGNIGSFNLG SGNQGDINLG IGNVGNLNLG SGNFGSQNLG SGNIGSTNVG SGNIGSTNVG
      301 SGNIGDTNFG NGNNGNFNFG SGNTGSNNIG FGNTGSGNFG FGNTGNNNIG IGLTGDGQIG
      361 IGGLNSGSGN IGFGNSGTGN VGLFNSGTGN VGFGNSGTAN TGFGNAGNVN TGFWNGGSTN
      421 TGLANAGAGN TGFFDAGNYN FGSLNAGNIN SSFVGRG
//