LOCUS       SIU00968.1               515 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            NITRITE EXTRUSION PROTEIN 1 NARK1 (NITRITE FACILITATOR
            1) protein.
ACCESSION   LT708304-2382
PROTEIN_ID  SIU00968.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="narK1"
                     /locus_tag="BQ2027_MB2356C"
                     /note="Mb2356c, narK1, len: 515 aa. Equivalent to Rv2329c,
                     len: 515 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 515 aa overlap). Probable narK1,
                     nitrite extrusion protein, possibly member of major
                     facilitator superfamily (MFS). Equivalent to
                     O32974|MLCB22.41c|NARK|ML0844 PUTATIVE NITRITE EXTRUSION
                     PROTEIN from Mycobacterium leprae (517 aa), FASTA scores:
                     opt: 2224, E(): 1.9e-129, (69.3% identity in 488 aa
                     overlap). Also highly similar to others e.g. P94933
                     NITRITE EXTRUSION PROTEIN from Mycobacterium fortuitum
                     (471 aa), FASTA scores: opt: 1969, E(): 8.6e-114, (62.1%
                     identity in 459 aa overlap); P37758|NARU_ECOLI NITRITE
                     EXTRUSION PROTEIN 2 from Escherichia coli strain K12 (462
                     aa), FASTA scores: opt: 792, E(): 2.3e-41, (36.95%
                     identity in 476 aa overlap); P10903|NARK_ECOLI nitrite
                     extrusion protein (nitrite facilitator 1) from Escherichia
                     coli strain K12 (463 aa), FASTA scores: opt: 784, E():
                     7e-41, (35.3% identity in 468 aa overlap); etc. Also
                     similar to RV0261c|Z86089|MTCY6A4_5 from Mycobacterium
                     tuberculosis (469 aa), FASTA scores: opt: 2000, E():
                     1.1e-115, (62.6% identity in 470 aa overlap). BELONGS TO
                     THE NARK/NASA FAMILY OF TRANSPORTERS."
                     /db_xref="GOA:A0A1R3Y0T4"
                     /db_xref="InterPro:IPR011701"
                     /db_xref="InterPro:IPR036259"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y0T4"
BEGIN
        1 MEQHTLLQRE ESPRSPAAPS LRRLGGSRHI THWDPEDLGA WEAGNKGIAR RNLLWSVVTV
       61 HLGYSVWTLW PVLELLMPQD VYGFSTSDKF LLGTIATLFG AFLRMPYALA SAIFGGRNWA
      121 TFSAIVLLIP AIGTTVLLTH PGLPLWPYLV CAALTGLGGG NFASSMSNAN AFYPHRLKGS
      181 ALGIAGGVGN LGVPAIQLVG LLAIATVGER KPYLVCALYV VLVAIAVIGV SLFMNNVEQH
      241 RVQVNRLRPI VSAVLSTRDT WLLSLLYLGT FGSFIGFSFV FGQVLQTNFL ACGQSPARAT
      301 LHAVELAFVG PLLAAVARIY GGRLADRVGG SRLTLIVFVA MTLAAGLLIS ASTLEGRHVG
      361 QHRGATMVGY FVCFVALFVL SGLGNGSVYK MIPTIFEACS RSLDLSEAER RDWSRIISGV
      421 VIGFVAAFGA LGGVGINMAL RESYLSTGSG TDAFWIFMMC YAAAAVLTWK VYDRRTVTDM
      481 GMLQAALVRQ PASTPAELIG PRTQSDRFSG CSISA
//