LOCUS       SIU00855.1               520 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Probable
            exported protease protein.
ACCESSION   LT708304-2269
PROTEIN_ID  SIU00855.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB2247C"
                     /note="Mb2247c, -, len: 520 aa. Equivalent to Rv2223c,
                     len: 520 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 520 aa overlap). Probable exported
                     protease (EC 3.4.-.-); has signal sequence. Very similar
                     to three proteases/peptidases from Streptomyces spp.:
                     L42758, L42759, L27466. FASTA score: L42758|STMSLPD
                     STMSLPD NID: g940302 - Streptomyces (539 aa) opt: 1032
                     E(): 0, (37.5% identity in 533 aa overlap). Also similar
                     to hypothetical proteins SW:YZZE _ECOLI P34211 (25.4%
                     identity in 406 aa overlap) and PIR:B36944 in ompP 3'
                     region (27.5% identity in 218 aa overlap). Highly similar
                     to Rv2224c and Rv2672 (49.3% identity in 507 aa overlap);
                     contains PS00120 Lipases, serine active site,Mb2247c found
                     to be expressed during exponential growth in Sauton's
                     minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:P65822"
                     /db_xref="InterPro:IPR000073"
                     /db_xref="InterPro:IPR013595"
                     /db_xref="InterPro:IPR029058"
                     /db_xref="UniProtKB/Swiss-Prot:P65822"
BEGIN
        1 MAAMWRRRPL SSALLSFGLL LGGLPLAAPP LAGATEEPGA GQTPGAPVVA PQQSWNSCRE
       61 FIADTSEIRT ARCATVSVPV DYDQPGGTQA KLAVIRVPAT GQRFGALLVN PGGPGASAVD
      121 MVAAMAPAIA DTDILRHFDL VGFDPRGVGH STPALRCRTD AEFDAYRRDP MADYSPAGVT
      181 HVEQVYRQLA QDCVDRMGFS FLANIGTASV ARDMDMVRQA LGDDQINYLG YSYGTELGTA
      241 YLERFGTHVR AMVLDGAIDP AVSPIEESIS QMAGFQTAFN DYAADCARSP ACPLGTDSAQ
      301 WVNRYHALVD PLVQKPGKTS DPRGLSYADA TTGTINALYS PQRWKYLTSG LLGLQRGSDA
      361 GDLLVLADDY DGRDADGHYS NDQDAFNAVR CVDAPTPADP AAWVAADQRI RQVAPFLSYG
      421 QFTGSAPRDL CALWPVPATS TPHPAAPAGA GKVVVVSTTH DPATPYQSGV DLARQLGAPL
      481 ITFDGTQHTA VFDGNQCVDS AVMHYFLDGT LPPTSLRCAP
//