LOCUS       SIU00724.1               374 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            5'-3' exonuclease protein.
ACCESSION   LT708304-2138
PROTEIN_ID  SIU00724.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB2117"
                     /note="Mb2117, -, len: 374 aa. Equivalent to Rv2090, len:
                     393 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (94.7% identity in 393 aa overlap). Probable 5'-3'
                     exonuclease, similar to exonuclease part of DNA
                     polymerase, e.g. DPO1_MYCTU Q07700 DNA polymerase I (EC
                     2.7.7.7) (pol i) (904 aa), FASTA scores, opt: 461, E():
                     1.2e-17, (38.7% identity in 292 aa overlap). BELONGS TO
                     FAMILY A OF DNA POLYMERASES.
                     REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a
                     57 bp in-frame deletion leads to a shorter product
                     compared to its homolog in Mycobacterium tuberculosis
                     strain H37Rv (374 aa versus 393 aa). Protein product from
                     Mb2117 detected using SWATH mass spectrometry."
                     /db_xref="GOA:A0A1R3Y2B9"
                     /db_xref="InterPro:IPR002421"
                     /db_xref="InterPro:IPR008918"
                     /db_xref="InterPro:IPR020045"
                     /db_xref="InterPro:IPR020046"
                     /db_xref="InterPro:IPR029060"
                     /db_xref="InterPro:IPR036279"
                     /db_xref="InterPro:IPR038969"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y2B9"
BEGIN
        1 MPAPDPMRGD PPHPAPPRLR SPLDPTSGDP LHPAPPRLRS PLDPTSGDPL HPAPPRLRSP
       61 LVLLDGASMW FRSFFGVPSS ITAPDGRPVN AVRGFIDSMA VVIIQQRPNR LAVCLDLDWR
      121 PQFRVDLIPS YKAHRVAEPE PNGQPDVEEV PDELTPQVDM IMELLDAFGI AMAGAPGFEA
      181 DDVLGTLATR ERRDPVIVVS GDRDLLQVVA DDPVPVRVLY LGRGLAKATL FGPAEVAERY
      241 GLPAHRAGAA YAELALLRGD PSDGLPGVPG VGEKTAATLL ARHGSLDQIM AAADDRKTTM
      301 AKGLRTKLLA ASAYIKAADR VVRVATDAPV TLSTPTDRLP LVAADPERTA ELATRFGVES
      361 SIARLQKALD TLPG
//