LOCUS       SIU00657.1               332 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 conserved
            membrane protein protein.
ACCESSION   LT708304-2070
PROTEIN_ID  SIU00657.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB2050C"
                     /note="Mb2050c, -, len: 332 aa. Equivalent to Rv2025c,
                     len: 332 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 332 aa overlap). Possible conserved
                     transmembrane protein, CDF family possibly involved in
                     transport of metal ions, similar to several hypothetical
                     bacterial proteins e. g. Methanobacterium
                     thermoautotrophicum AE000941_1 (298 aa; described as
                     cation efflux system protein) and Archaeoglob us fulgidus
                     AE001111_5 (384 aa). FASTA scores: AE000941_1 M
                     ethanobacterium thermoautotrophicum (298 aa) opt: 452 E():
                     3.3e-24; 30.8% identity in 266 aa overlap and AE001111_5
                     Archaeoglobus fulgidus section 16 (384 aa) opt: 371 E():
                     1.7e-18; 27.7% identity in 267 aa overlap. TBparse score
                     is 0.897 Protein product from Mb2050c detected using SWATH
                     mass spectrometry."
                     /db_xref="GOA:A0A1R3Y0D1"
                     /db_xref="InterPro:IPR002524"
                     /db_xref="InterPro:IPR027469"
                     /db_xref="InterPro:IPR027470"
                     /db_xref="InterPro:IPR036837"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y0D1"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MTHDHAHSRG VPAMIKEIFA PHSHDAADSV DDTLESTAAG IRTVKISLLV LGLTALIQIV
       61 IVVMSGSVAL AADTIHNFAD ALTAVPLWIA FALGAKPATR RYTYGFGRVE DLAGSFVVAM
      121 ITMSAIIAGY EAIARLIHPQ QIEHVGWVAL AGLVGFIGNE WVALYRIRVG HRIGSAALIA
      181 DGLHARTDGF TSLAVLCSAG GVALGFPLAD PIVGLLITAA ILAVLRTAAR DVFRRLLDGV
      241 DPAMVDAAEQ ALAARPGVQA VRSVRMRWIG HRLHADAELD VDPALDLAQA HRIAHDAEHE
      301 LTHTVPKLTT ALIHAYPAEH GSSIPDRGRT VE
//