LOCUS       SIU00611.1               558 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 pe-
            pgrs family protein pe_pgrs35 protein.
ACCESSION   LT708304-2024
PROTEIN_ID  SIU00611.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="PE_PGRS35"
                     /locus_tag="BQ2027_MB2005"
                     /note="Mb2005, PE_PGRS35, len: 558 aa. Equivalent to
                     Rv1983, len: 558 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (99.8% identity in 558 aa overlap). Member
                     of the Mycobacterium tuberculosis PE family, PGRS
                     subfamily of gly-rich proteins. Similar to other PE
                     proteins e.g. Rv0977, etc. Contains PS00141 Eukaryotic and
                     viral aspartyl proteases active site. Mb2005 found to be
                     expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="InterPro:IPR000084"
                     /db_xref="InterPro:IPR021109"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XZU6"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MSFLVVVPEF LTSAAADVEN IGSTLRAANA AAAASTTALA AAGADEVSAA VAALFARFGQ
       61 EYQAVSAQAS AFHQQFVQTL NSASGSYAAA EATIASQLQT AQHDLLGAVN APTETLLGRP
      121 LIGDGAPGTA TSPNGGAGGL LYGNGGNGYS ATASGVGGGA GGSAGLIGNG GAGGAGGPNA
      181 PGGAGGNGGW LLGNGGIGGP GGASSIPGMS GGAGGTGGAT GLLGWGANGG AGGLGDGVGV
      241 DRGTGGAGGR GGLLYGGYGV SGPGGDGRTV PLEIIHVTEP TVHANVNGGP TSTILVDTGS
      301 AGLVVSPEDV GGILGVLHMG LPTGLSISGY SGGLYYIFAT YTTTVDFGNG IVTAPTAVNV
      361 VLLSIPTSPF AISTYFSALL ADPTTTPFEA YFGAVGVDGV LGVGPNAVGP GPSIPTMALP
      421 GDLNQGVLID APAGELVFGP NPLPAPNVEV VGSPITTLYV KIDGGTPIPV PSIIDSGGVT
      481 GTIPSYVIGS GTLPANTNIE VYTSPGGDRL YAFNTNDYRP TVISSGLMNT GFLPFRFQPV
      541 YIDYSPSGIG TTVFDHPA
//