LOCUS       SIU00556.1               625 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PPE
            FAMILY PROTEIN protein.
ACCESSION   LT708304-1969
PROTEIN_ID  SIU00556.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="PPE35a"
                     /locus_tag="BQ2027_MB1953C"
                     /note="Mb1953c, PPE35a, len: 625 aa. Equivalent to 5'end
                     of Rv1918c, len: 987 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (100.0% identity in 599 aa overlap). Member
                     of the Mycobacterium tuberculosis PPE family of
                     glycine-rich proteins. Similar to MTCY28.16|Z95890 M.
                     tuberculosis cosmid (1053 aa), FASTA scores: opt: 3404,
                     E(): 0, (65.6% identity in 1058 aa overlap). Also similar
                     to MTV004.05, MTY13E10.17, MTV014.03, MTCY3C7.23,
                     MTCY6G11.05, MTCY48.17, MTV004.03, MTCY31.07, MTCY4C12.36,
                     MTCY180.01, etc. REMARK-M.bovis-M.tuberculosis: In
                     Mycobacterium tuberculosis strain H37Rv, PPE35 exists as a
                     single gene. In Mycobacterium bovis, a frameshift due to a
                     single base insertion (*-t) splits PPE35 into 2 parts,
                     PPE35a and PPE35b. Mb1953c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="InterPro:IPR000030"
                     /db_xref="InterPro:IPR002989"
                     /db_xref="InterPro:IPR038332"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XZR2"
BEGIN
        1 MHYSVLPPEI NSALIFAGAG SGPMLAAASA WDGLATELAS AAVSFGSVTA GLVGGSWQGR
       61 SSVAMAAAAA PYAGWLAAAA TQAEQAATQA QVMVAEFEAV RLAMVQPALV AANRSGLISL
      121 VISNLFGQNA PAIAAAEAAY EEMWALDVSA MAAYHSGASA VAVALPAFAL PLRLPAGLAA
      181 GPAAVVTALT TAVGMPTFAG RAIAASLGLA NVGGGNLGNA NNGLGNIGNA NLGNNNLGSG
      241 NFGSFNIGSA NLGGNNIGIG NAGANNFGLA NLGNLNTGFA NAGIGNFGIA NTGNNNIGNG
      301 LTGNNQIGIG GLNSGNGNVG LFNAGSANIG FFNSGNGNFG IGNSGNFSTG LFNPGHGNTG
      361 FLNAGSFNTG MFDVGNANTG SFNVGHYNFG AFNPGPSNTG TFNTGGANTG WFNTGSINTG
      421 AFNIGDMNNG LFNTGDMNNG VFYRGVGQGS LQFAITSPDL TLPSLEIPGI SVPAFSLPAI
      481 TLPSLTIPAV TTPANVTVGA FDLPGLTVPS LTIPAAMTPA NITVGAFDLP GLTVPSLTIP
      541 ATTTPANITV GAFNLPQLSI PSVTVPPITI PAGTALGAFN LPTLSIPSVT VPPITIPAGN
      601 HCRRIYATHD THPVNKYTPN KYRRL
//