LOCUS       SIU00478.1               264 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE)
            (IMPDH) (IMPD) protein.
ACCESSION   LT708304-1891
PROTEIN_ID  SIU00478.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="guaB1"
                     /locus_tag="BQ2027_MB1874C"
                     /note="Mb1874c, guaB1, len: 479 aa. Equivalent to Rv1843c,
                     len: 479 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 479 aa overlap). Probable guaB1,
                     inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205).
                     Similar to others e.g. IMDH_BACSU|P21879 from Bacillus
                     subtilis (513 aa), FASTA score: opt: 904, E(): 0, (37.8%
                     identity in 471 aa overlap). Similar to other
                     Mycobacterium tuberculosis proteins e.g. guaB2, Rv3411c.
                     Protein product from Mb1874c detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb1874c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:P65173"
                     /db_xref="InterPro:IPR000644"
                     /db_xref="InterPro:IPR001093"
                     /db_xref="InterPro:IPR005990"
                     /db_xref="InterPro:IPR005991"
                     /db_xref="InterPro:IPR013785"
                     /db_xref="UniProtKB/Swiss-Prot:P65173"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MRIGAAVGIN GDVGAKARAL AEAGVDVLVI DTAHGHQVKT LDAIKAVSAL DLGLPLAAGN
       61 VVSAEGTRDL LKAGANVVKV GVGPGAMCTT RMMTGVGRPQ FSAVLECASA ARQLGGHIWA
      121 DGGIRHPRDV ALALAAGASN VMIGSWFAGT YESPGDLMRD RDDQPYKESY GMASKRAVVA
      181 RTGADNPFDR ARKALFEEGI STSRMGLDPD RGGVEDLIDH ITSGVRSTCT YVGASNLAEL
      241 HERAVVGVQS GAGFAEGHPL PAGW
//