LOCUS       SIU00435.1               540 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PE-
            PGRS FAMILY PROTEIN [SECOND PART] protein.
ACCESSION   LT708304-1848
PROTEIN_ID  SIU00435.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="PE_PGRS32b"
                     /locus_tag="BQ2027_MB1831C"
                     /note="Mb1831c, PE_PGRS32b, len: 540 aa. Equivalent to 3'
                     end of Rv1803c, len: 639 aa, from Mycobacterium
                     tuberculosis strain H37Rv, (100.0% identity in 540 aa
                     overlap). Member of the Mycobacterium tuberculosis PE
                     family, PGRS subfamily of gly-rich proteins. Most similar
                     to Rv1768|MTCY28.34|Z95890 (618 aa), FASTA scores: opt:
                     1827, E(): 0, (53.5% identity in 664 aa overlap). Contains
                     two PS00583 pfkB family of carbohydrate kinases signatures
                     1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium
                     tuberculosis strain H37Rv, PE_PGRS32 exists as a single
                     gene. In Mycobacterium bovis, a frameshift due to a single
                     base transition (c-t) splits PE_PGRS32 into 2 parts,
                     PE_PGRS32a and PE_PGRS32b, with PE_PGRS32a being
                     truncated. Mb1831c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XZE5"
BEGIN
        1 MQIVGQTALD AINSPVQTLT GRPLIGNGAN GVAGTGQNGG DGGWLYGNGG NGGSGGTGQN
       61 GGNGGSAGLW GSGGNGGQGG AGANGAAGQP GKAGGSGGNG GAGGWIYGHG GHGGAGGNGG
      121 NATAPGGASA GFDGGAGGNG GSGGRGGLLF GNGGNGSVGG MGGQGTNDTA GDSAGSGGLG
      181 GNGGNGAQGG WLIGNGGQGG DSGAGGGTDS TQTGVMNGAS GGSAGIAGNG GDAGLVGNGG
      241 AGGNGGNGAA GSALGTTIFG GSGGVGGSGG DGGNGGWLFG SGASGGNGGQ GGDAGTNGFA
      301 GFGGSAGGGG WVGAVNFGPI SVQGFGLFGH GGDGGNGGDV GAGSLSIQFG ASGGDGGQGG
      361 VLYGNGGNGG NAGSGGGTGF EGSAGQGGAA ILIGNGGAGG NGATGGTGVG NIIQEAGGDG
      421 SDGGAGGSGG LLFGSGGAGG IGGAGGVGGS GNDGGNGGDG GQGGASGLGI GNGGPGGSGG
      481 TGGAGGTGGS AGTGGAGGDG GNAALLIGTG GDGGDGVPPA PGGQGGKGGL IGLPGQNGQP
//