LOCUS       SIU00230.1               380 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Probable
            histidinol-phosphate aminotransferase hisC1 protein.
ACCESSION   LT708304-1643
PROTEIN_ID  SIU00230.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="hisC1"
                     /locus_tag="BQ2027_MB1626"
                     /standard_name="hisC"
                     /note="Mb1626, hisC1, len: 380 aa. Equivalent to Rv1600,
                     len: 380 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 380 aa overlap). Probable hisC1,
                     histidinol-phosphate aminotransferase (EC 2.6.1.9) O06591.
                     Similar to many e.g. HIS8_STRCO|P16246 from Streptomyces
                     coelicolor (369 aa), FASTA results: opt: 1353, E(): 0,
                     (59.0% identity in 356 aa overlap). Some similarity to
                     other Mycobacterium tuberculosis aminotransferases e.g.
                     Rv3772|MTCY13D12.06, FASTA results: E(): 7.4e-25, (33.7%
                     identity in 365 aa overlap). Contains aminotransferases
                     class-II pyridoxal-phosphate attachment site (PS00599).
                     BELONGS TO CLASS-II OF PYRIDOXAL-PHOSPHATE-DEPENDENT
                     AMINOTRANSFERASES. Note that previously known as hisC.
                     Protein product from Mb1626 detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb1626 found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:P0A679"
                     /db_xref="InterPro:IPR001917"
                     /db_xref="InterPro:IPR004839"
                     /db_xref="InterPro:IPR005861"
                     /db_xref="InterPro:IPR015421"
                     /db_xref="InterPro:IPR015422"
                     /db_xref="InterPro:IPR015424"
                     /db_xref="UniProtKB/Swiss-Prot:P0A679"
BEGIN
        1 MTRSGHPVTL DDLPLRADLR GKAPYGAPQL AVPVRLNTNE NPHPPTRALV DDVVRSVREA
       61 AIDLHRYPDR DAVALRADLA GYLTAQTGIQ LGVENIWAAN GSNEILQQLL QAFGGPGRSA
      121 IGFVPSYSMH PIISDGTHTE WIEASRANDF GLDVDVAVAA VVDRKPDVVF IASPNNPSGQ
      181 SVSLPDLCKL LDVAPGIAIV DEAYGEFSSQ PSAVSLVEEY PSKLVVTRTM SKAFAFAGGR
      241 LGYLIATPAV IDAMLLVRLP YHLSSVTQAA ARAALRHSDD TLSSVAALIA ERERVTTSLN
      301 DMGFRVIPSD ANFVLFGEFA DAPAAWRRYL EAGILIRDVG IPGYLRATTG LAEENDAFLR
      361 ASARIATDLV PVTRSPVGAP
//