LOCUS       SIU00217.1               333 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Partial
            REP13E12 repeat protein protein.
ACCESSION   LT708304-1630
PROTEIN_ID  SIU00217.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB1613C"
                     /note="Mb1613c, -, len: 333 aa. Equivalent to Rv1587c,
                     len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (97.2% identity in 217 aa overlap). Partial REP13E12
                     repeat protein (see citation below), nearly identical (but
                     has been interrupted by phiRv1 prophage) to
                     Q50655|MTCY251.13c HYPOTHETICAL 34.6 KD PROTEIN from M.
                     tuberculosis (317 aa), FASTA results: opt: 2020, E(): 0,
                     (98.0% identity in 302 aa overlap); Rv0094c|MTCY251.13c
                     (317 aa), FASTA results: E(): 0, (100.0% identity in 217
                     aa overlap). Codon usage suggests that translation may
                     involve frameshifting of Rv1588c mRNA in poly_C stretch
                     into reading frame of Rv1587c. 3' end found in Rv1572c.
                     REMARK-M.bovis-M.tuberculosis: In Mycobacterium
                     tuberculosis strain H37Rv and Mycobacterium bovis, Rv1587
                     possibly exists as a pseudogene that has been disrupted
                     when the phage entered. Mb1613c found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="InterPro:IPR003615"
                     /db_xref="InterPro:IPR003870"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XYS5"
BEGIN
        1 MLAKLAAPGA TNPDDHTPVI DTTPDAAAID RDTRSQAQRN HDGLLAGLRA LIASGELGQH
       61 NGLPVSIVVT TTLTDLQTGA GKGFTGGGTL LPMADVIRMT SHAHHYSPAS GRYPQAIFDH
      121 GTPLALYHTK RLASPAQRIM LFANDRGCTK PGCDAPAYHS QAHHVTGWTS TGRTDITDLT
      181 LACDPDNRLA EKGWTTRKNT HGHTEWLPPP HLDHGQPWTC EIHYTCACCC LPPNLRRPLR
      241 RTARRGPPTR GLPKAVRAAK MGARRVPRQR RQRINRQAPP RLRADVGRHH RRQDRRRGGL
      301 GPGPAPSPSH RAGSLHVISR REAAGPGHRR RRR
//