LOCUS       SIU00186.1               967 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL6 protein.
ACCESSION   LT708304-1599
PROTEIN_ID  SIU00186.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="mmpL6"
                     /locus_tag="BQ2027_MB1583"
                     /note="Mb1583, mmpL6, len: 967 aa. Equivalent to 3' end of
                     Rv1557, len: 397 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (99.5% identity in 384 aa overlap). Probable
                     mmpL6, conserved transmembrane transport protein (see
                     citations below). Member of RND superfamily, with strong
                     similarity to other members of large Mycobacterial
                     membrane protein family belonging to RND superfamily e.g.
                     Q11171|MML2_MYCTU|MMPL2|Rv0507|MT0528|MTCY20G9.34 PROBABLE
                     CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN from
                     Mycobacterium tuberculosis (968 aa), FASTA scores: opt:
                     4142, E(): 0, (64.4% identity in 947 aa overlap);
                     O53735|MML4_MYCTU|MMPL4|Rv0450c|MT0466|MTV037.14c PROBABLE
                     CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN from
                     Mycobacterium tuberculosis (967 aa), FASTA scores: opt:
                     4035, E(): 0, (61.5% identity in 948 aa overlap);
                     P54881|MML4_MYCLE|MMPL4|ML2378|U1740V Putative membrane
                     protein from Mycobacterium leprae (959 aa), FASTA scores:
                     opt: 3961, E(): 0, (60.95% identity in 945 aa overlap);
                     etc. BELONGS TO THE MMPL FAMILY.
                     REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a
                     2153 bp insertion leads to a longer product compared to
                     its homolog in Mycobacterium tuberculosis strain H37Rv.
                     Belongs to the TbD1 region. Mb1583 found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XZ18"
                     /db_xref="InterPro:IPR000731"
                     /db_xref="InterPro:IPR004707"
                     /db_xref="InterPro:IPR004869"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XZ18"
BEGIN
        1 MSNHHRPRPW LPHTIRRLSL PILLFWVGVA AITNAAVPQL EVVGEAHNVA QSSPDDPSLQ
       61 AMKRIGKVFH EFDSDSAAMI VLEGDKPLGN DAHRFYDTLL RNLSNDTKHV EHVQDFWGDP
      121 LTAAGSQSTD GKAAYVQVYL AGNQGEALSI ESVDAVRDIV AHTPPPAGVK AYVTGAAPLM
      181 ADQFQVGSKG TAKVTGITLV VIAVMLLFVY RSVVTMVLVL ITVLIELAAA RGIVAFLGNA
      241 GVIGLSTYST NLLTLLVIAA GTDYAIFVLG RYHEARYAAQ DRETAFYTMY RGTAHVVLGS
      301 GLTVAGAVYC LSFTRLPYFQ SLGIPASIGV MIALAAALSL APSVLILGSR FGCFEPKRRM
      361 RTRGWRRIGT AIVRWPGPIL AVACAIAVVG LLALPGYKTS YDARYYMPAT APANIGYMAA
      421 ERHFPQARLN PELLMIETDH DMRNPADMLI LDRIAKAVFH LPGIGLVQAM TRPLGTPIDH
      481 SSIPFQISMQ SVGQIQNLKY QRDRAADLLK QAEELGKTIE ILQRQYALQQ ELAAATHEQA
      541 ESFHQTIATV KELRDRIANF DDFFRPIRSY FYWEKHCYDI PSCWALRSVF DTIDGIDQLG
      601 EQLASVTVTL DKLAAIQPQL VALLPDEIAS QQINRELALA NYATMSGIYA QTAALIENAA
      661 AMGQAFDAAK NDDSFYLPPE AFDNPDFQRG LKLFLSADGK AARMIISHEG DPATPEGISH
      721 IDAIKQAAHE AVKGTPMAGA GIYLAGTAAT FKDIQDGATY DLLIAGIAAL SLILLIMMII
      781 TRSLVAALVI VGTVALSLGA SFGLSVLVWQ HLLGIQLYWI VLALAVILLL AVGSDYNLLL
      841 ISRFKEEIGA GLNTGIIRAM AGTGGVVTAA GLVFAATMSS FVFSDLRVLG QIGTTIGLGL
      901 LFDTLVVRAF MTPSIAVLLG RWFWWPQRVR PRPASRMLRP YGPRPVVREL LLREGNDDPR
      961 TQVATHR
//