LOCUS       SIU00065.1               535 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            LONG-CHAIN-FATTY-ACID--COA LIGASE FADD12 (FATTY-ACID-COA
            SYNTHETASE) (FATTY-ACID-COA SYNTHASE) protein.
ACCESSION   LT708304-1478
PROTEIN_ID  SIU00065.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="fadD12"
                     /locus_tag="BQ2027_MB1462C"
                     /note="Mb1462c, fadD12, len: 535 aa. Equivalent to
                     Rv1427c, len: 535 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (100% identity in 535 aa overlap). Possible
                     fadD12, long-chain-fatty-acid-CoA synthetase (EC 6.2.1.-),
                     similar to many e.g. NP_302632.1|NC_002677 acyl-CoA
                     synthase from Mycobacterium leprae (548 aa);
                     AAD01929.2|AF031419 putative long-chain-fatty-acid--CoA
                     ligase from Pseudomonas putida (565 aa);
                     NP_419782.1|NC_002696 putative long-chain-fatty-acid--CoA
                     ligase from Caulobacter crescentus (530 aa);
                     PC60_YEAST|P38137 yeast peroxisomal-coenzyme A synthetase
                     (543 aa), FASTA scores: opt: 507, E(): 2.9e-25, (30.4%
                     identity in 365 aa overlap). Also similar to many M.
                     tuberculosis proteins e.g. MTCY06A4.14 (44.8% identity in
                     525 aa overlap). Contains PS00455 Putative AMP-binding
                     domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING
                     ENZYME FAMILY. Protein product from Mb1462c detected using
                     shotgun mass spectrometry and SWATH mass spectrometry.
                     Mb1462c found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3XYB5"
                     /db_xref="InterPro:IPR000873"
                     /db_xref="InterPro:IPR020845"
                     /db_xref="InterPro:IPR025110"
                     /db_xref="InterPro:IPR042099"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XYB5"
BEGIN
        1 MRIRQAFGLI ATMRRAGLIA PLRPDRYLRI VAAMRREGMG FTAGFAGAAR RCPDRPGLID
       61 ELGTLTWRQL DERGNALAAA LQALPAGPPR VVGIMCRNHR GFVDALLAVN RIGAHILLLN
      121 TSFAGPALAE VVTREGVDTV VYDEEFSATV DRALAEKPQA TRIVAWTDED HDLTVEKLVA
      181 AHAGRRPEHT GSHGKVILLT SGTTGTPKGA RHSGGGIGTL KAILDRTPWR AEEVTVIVAP
      241 MFHAWGFSQL VLASSLACTI VTRRRFDPEA TLDLIDRHHA TGLVVVPVMF DRIMDLPAEI
      301 RNRYDGRSLR FAAASGSRMR PDVVIAFMDQ FGDVIYNNYN ATEAGMIATA TPADLRTAPD
      361 TAGRPAEGTE IRILDQQFTE VPTGEVGTIY VRNDSQFDGY TSGAAKDFHA GFMSSGDVGY
      421 LDENGRLFVV GRDDEMIVSG GENIYPIEVE KTLATHPDVA EAAVIGVDDQ QYGQRLAAFV
      481 VLKPGVSATP ETLKQHVRDN LANYKVPRDI AVLDELPRGI TGKILRTELQ SRVGS
//