LOCUS       SIT99802.1               180 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PPE
            FAMILY PROTEIN [FIRST PART] protein.
ACCESSION   LT708304-1214
PROTEIN_ID  SIT99802.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="PPE17a"
                     /locus_tag="BQ2027_MB1201C"
                     /note="Mb1201c, PPE17a, len: 180 aa. Similar to 5' end of
                     Rv1168c, len: 346 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (97.1% identity in 174 aa overlap). Member
                     of the Mycobacterium tuberculosis PPE family of
                     glycine-rich proteins, similar to many e.g.
                     E332789|Z98268|MTCI125.27C (385 aa), FASTA scores: opt:
                     504, E(): 0, (36.6% identity in 388 aa overlap).
                     REMARK-M.bovis-M.tuberculosis: In Mycobacterium
                     tuberculosis strain H37Rv, PPE17 exists as a single gene.
                     In Mycobacterium bovis, a frameshift due to a single base
                     insertion (*-c) splits PPE17 into 2 parts, PPE17a and
                     PPE17b. Mb1201c found to be expressed during exponential
                     growth in Sauton's minimal media by RNA-sequencing (TPM >
                     20)."
                     /db_xref="InterPro:IPR000030"
                     /db_xref="InterPro:IPR038332"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XZN0"
BEGIN
        1 MDFTIFPPEF NSLNIQGSAR PFLVAANAWK NLSNELSYAA SRFESEINGL ITSWRGPSST
       61 IMAAAVAPFR AWIVTTASLA ELVADHISVV AGAYEAAHAA HVPLPVIETN RLTRLALATT
      121 NIFGIHTPAI FALDALYAQY WSQDGEAMNL YATMAAAAAR LTPFSPPGAD RQPGRAGQTL
//