LOCUS       SIT99539.1               593 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            GLYCINE BETAINE TRANSPORT INTEGRAL MEMBRANE PROTEIN BETP
            protein.
ACCESSION   LT708304-951
PROTEIN_ID  SIT99539.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="betP"
                     /locus_tag="BQ2027_MB0941"
                     /note="Mb0941, betP, len: 593 aa. Equivalent to Rv0917,
                     len: 593 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 593 aa overlap). Possible betP, glycine
                     betaine transporter, integral membrane protein, highly
                     similar to many transporters, mainly glycine betaine
                     transporters, e.g. P54582|BETP_CORGL glycine betaine
                     transporter from Corynebacterium glutamicum
                     (Brevibacterium flavum) (595 aa), FASTA scores: opt: 1367,
                     E(): 0, (42.7% identity in 504 aa overlap); T35264
                     probable BCCT family transporter from Streptomyces
                     coelicolor (578 aa); NP_243511.1|NC_002570 glycine betaine
                     transporter from Bacillus halodurans (504 aa);
                     NP_439848.1|NC_000907 high-affinity choline transport
                     protein (betT) from Haemophilus influenzae (669 aa); etc.
                     SEEMS TO BELONG TO THE BCCT (TC 2.33) FAMILY OF
                     TRANSPORTERS. Mb0941 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P63696"
                     /db_xref="InterPro:IPR000060"
                     /db_xref="InterPro:IPR018093"
                     /db_xref="UniProtKB/Swiss-Prot:P63696"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MSAKERGDQN AVVDALRSIQ PAVFIPASVV IVAMIVVSVV YSSVAENAFV RLNSAITGGV
       61 GWWYILVATG FVVFALYCGI SRIGTIRLGR DDELPEFSFW AWLAMLFSAG MGIGLVFYGV
      121 AEPLSHYLRP PRSRGVPALT DAAANQAMAL TVFHWGLHAW AIYVVVGLGM AYMTYRRGRP
      181 LSVRWLLEPV VGRGRVEGAL GHAVDVIAIV GTLFGVATSL GFGITQIASG LEYLGWIRVD
      241 NWWMVGMIAA ITATATASVV SGVSKGLKWL SNINMALAAA LALFVLLLGP TLFLLQSWVQ
      301 NLGGYVQSLP QFMLRTAPFS HDGWLGDWTI FYWGWWISWA PFVGMFIARI SRGRTIREFI
      361 GAVLLVPTVI ASLWFTIFGD SALLRQRNNG DMLVNGAVDT NTSLFRLLDG LPIGAITSVL
      421 AVLVIVFFFV TSSDSGSLVI DILSAGGELD PPKLTRVYWA VLEGVAAAVL LLIGGAGSLT
      481 ALRTAAIATA LPFSIVMVVA CYAMTKAFHF DLAATPRLLH VTVPDVVAAG NRRRHDISAT
      541 LSGLIAVRDV DSGTYIVHPD TGALTVTAPP DPLDDHVFES DRHVTRRNTT SSR
//