LOCUS       SIT98443.1               745 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            ISOCITRATE DEHYDROGENASE [NADP] ICD2 (OXALOSUCCINATE DECARBOXYLASE)
            (IDH) (NADP+-SPECIFIC ICDH) (IDP) protein.
ACCESSION   LT708304-68
PROTEIN_ID  SIT98443.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="icd2"
                     /locus_tag="BQ2027_MB0067C"
                     /note="Mb0067c, icd2, len: 745 aa. Equivalent to Rv0066c,
                     len: 745 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.9% identity in 745 aa overlap). Probable icd2,
                     isocitrate dehydrogenase NADP-dependant (EC 1.1.1.42),
                     equivalent to NP_302705.1|NC_002677 isocitrate
                     dehydrogenase [NADP] from Mycobacterium leprae (746 aa).
                     Also highly similar to many members of the monomeric-type
                     family of IDH e.g. NP_251314.1|NC_002516 isocitrate
                     dehydrogenase from Pseudomonas aeruginosa (741 aa);
                     IDH_AZOVI|P16100 isocitrate dehydrogenase (nadp) from
                     Azotobacter vinelandii (741 aa), FASTA scores: opt: 3106,
                     E(): 0, (61.4% identity in 735 aa overlap);
                     NP_230786.1|NC_002505 isocitrate dehydrogenase [Vibrio
                     cholerae (741 aa); etc. BELONGS TO THE MONOMERIC-TYPE
                     FAMILY OF IDH. Protein product from Mb0067c detected using
                     shotgun mass spectrometry and SWATH mass spectrometry.
                     Mb0067c found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3XWE0"
                     /db_xref="InterPro:IPR004436"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XWE0"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MSAEQPTIIY TLTDEAPLLA TYAFLPIVRA FAEPAGIKIE ASDISVAARI LAEFPDYLTE
       61 EQRVPDNLAE LGRLTQLPDT NIIKLPNISA SVPQLVAAIK ELQDKGYAVP DYPADPNTDQ
      121 EKAIKERYAR CLGSAVNPVL RQGNSDRRAP KAVKEYARKH PHSMGEWSMA SRTHVAHMRH
      181 GDFYAGEKSM TLDRARNVRM ELLAKSGKTI VLKPEVPLDD GDVIDSMFMS KKALCDFYEE
      241 QMQDAFETGV MFSLHVKATM MKVSHPIVFG HAVRIFYKDA FAKHQELFDD LGVNVNNGLS
      301 DLYSKIESLP ASQRDEIIED LHRCHEHRPE LAMVDSARGI SNFHSPSDVI VDASMPAMIR
      361 AGGKMYGADG KLKDTKAVNP ESTFSRIYQE IINFCKTNGQ FDPTTMGTVP NVGLMAQQAE
      421 EYGSHDKTFE IPEDGVANIV DVATGEVLLT ENVEAGDIWR MCIVKDAPIR DWVKLAVTRA
      481 RISGMPVLFW LDPYRPHENE LIKKVKTYLK DHDTEGLDIQ IMSQVRSMRY TCERLVRGLD
      541 TIAATGNILR DYLTDLFPIL ELGTSAKMLS VVPLMAGGGM YETGAGGSAP KHVKQLVEEN
      601 HLRWDSLGEF LALGAGFEDI GIKTGNERAK LLGKTLDAAI GKLLDNDKSP SRKTGELDNR
      661 GSQFYLAMYW AQELAAQTDD QQLAEHFASL ADVLTKNEDV IVRELTEVQG EPVDIGGYYA
      721 PDSDMTTAVM RPSKTFNAAL EAVQG
//