LOCUS       SIT98398.1               441 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            CONSERVED INTEGRAL MEMBRANE PROTEIN protein.
ACCESSION   LT708304-38
PROTEIN_ID  SIT98398.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0038C"
                     /note="Mb0038c, -, len: 441 aa. Equivalent to Rv0037c,
                     len: 441 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 441 aa overlap). Probable conserved
                     integral membrane protein, member of major facilitator
                     superfamily (MFS) possibly involved in transport of
                     macrolide, showing some similarity to Rv1258c|MTCY50_24
                     (419 aa), FASTA score: (25.2% identity in 408 aa overlap);
                     and to AL049826|SCH24_20 from Streptomyces coelicolor (425
                     aa), FASTA scores: opt: 725, E(): 0, (36.1% identity in
                     418 aa overlap). Also similarity with several
                     MACROLIDE-EFFLUX PROTEINS e.g. from S. pyogenes (405 aa),
                     FASTA scores: E(): 1.3e-06, (22.8% identity in 416 aa
                     overlap). Protein product from Mb0038c detected using
                     SWATH mass spectrometry."
                     /db_xref="GOA:P0A5C2"
                     /db_xref="InterPro:IPR011701"
                     /db_xref="InterPro:IPR036259"
                     /db_xref="UniProtKB/Swiss-Prot:P0A5C2"
BEGIN
        1 MPRVEVGLVI HSRMHARAPV DVWRSVRSLP DFWRLLQVRV ASQFGDGLFQ AGLAGALLFN
       61 PDRAADPMAI AGAFAVLFLP YSLLGPFAGA LMDRWDRRWV LVGANTGRLA LIAGVGTILA
      121 VGAGDVPLLV GALVANGLAR FVASGLSAAL PHVVPREQVV TMNSVAIASG AVSAFLGANF
      181 MLLPRWLLGS GDEGASAIVF LVAIPVSIAL LWSLRFGPRV LGPDDTERAI HGSAVYAVVT
      241 GWLHGARTVV QLPTVAAGLS GLAAHRMVVG INSLLILLLV RHVTARAVGG LGTALLFFAA
      301 TGLGAFLANV LTPTAIRRWG RYATANGALA AAATIQVAAA GLLVPVMVVC GFLLGVAGQV
      361 VKLCADSAMQ MDVDDALRGH VFAVQDALFW VSYILSITVA AALIPEHGHA PVFVLFGSAI
      421 YLAGLVVHTI VGRRGQPVIG R
//