LOCUS       SIT98358.1               232 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            ANTHRANILATE SYNTHASE COMPONENT II TRPG (GLUTAMINE AMIDOTRANSFERASE)
            protein.
ACCESSION   LT708304-13
PROTEIN_ID  SIT98358.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="trpG"
                     /locus_tag="BQ2027_MB0013"
                     /note="Mb0013, trpG, len: 232 aa. Equivalent to Rv0013,
                     len: 232 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.6% identity in 232 aa overlap). Possible trpG,
                     anthranilate synthase component II (glutamine
                     amidotransferase) (EC 4.1.3.27), equivalent to
                     NP_301141.1|NC_002677 putative p-aminobenzoate synthase
                     glutamine amidotransferase from Mycobacterium leprae (232
                     aa). Also highly similar to others e.g. P26922|TRPG_AZOBR
                     Anthranilate synthase component II from Azospirillum
                     brasilense (196 aa), FASTA scores: opt: 703, E(): 8.6e-40,
                     (56.7% identity in 187 aa overlap); T36720 probable
                     glutamine amidotransferase from Streptomyces coelicolor
                     (212 aa); T44524 anthranilate synthase from Nitrosomonas
                     europaea (199 aa); etc. Also similar to E235740
                     para-aminobenzoate synthase (232 aa), FASTA scores: opt:
                     1273, E(): 0, (79.7% identity in 232 aa overlap). Contains
                     PS00606 Beta-ketoacyl synthases active site; and PS00442
                     Glutamine amidotransferases class-I active site.
                     SIMILARITY TO OTHER TYPE-1 GLUTAMINE AMIDOTRANSFERASE
                     DOMAINS. Note that previously known as pabA. Protein
                     product from Mb0013 detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb0013 found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3XU22"
                     /db_xref="InterPro:IPR006221"
                     /db_xref="InterPro:IPR017926"
                     /db_xref="InterPro:IPR029062"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XU22"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MRILVVDNYD SFVFNLVQYL GQLGIEAEVW RNDDHRLSDE AAVAGQFDGV LLSPGPGTPE
       61 RAGASVSMVH ACAAAHTPLL GVCLGHQAIG VAFGATVDRA PELLHGKTSS VFHTNVGVLQ
      121 GLPDPFTATR YHSLTILPKS LPAVLRVTAR TSSGVIMAVQ HTGLPIHGVQ FHPESILTEG
      181 GHRILANWLT CCGWTQDDTL VRRLENEVLT AISPHFPTST ASAGEATGRT SA
//