LOCUS       SIT98345.1               838 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 DNA
            GYRASE (SUBUNIT A) GYRA (DNA TOPOISOMERASE (ATP-HYDROLYSING)
            ) (DNA TOPOISOMERASE II) (TYPE II DNA TOPOISOMERASE) protein.
ACCESSION   LT708304-6
PROTEIN_ID  SIT98345.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="gyrA"
                     /locus_tag="BQ2027_MB0006"
                     /note="Mb0006, gyrA, len: 838 aa. Equivalent to Rv0006,
                     len: 838 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.5% identity in 838 aa overlap). gyrA, DNA gyrase
                     subunit A (EC 5.99.1.3) (see citations below), equivalent,
                     except in N-terminus, to other Mycobacterial DNA GYRASES
                     SUBUNIT A e.g. Q57532|GYRA_MYCLE|T10006 from Mycobacterium
                     leprae (1273 aa); P48354|GYRA_MYCSM from Mycobacterium
                     smegmatis (842 aa); etc. Also highly similar to others
                     e.g. P35885|GYRA_STRCO DNA GYRASE SUBUNIT A from
                     Streptomyces coelicolor (864 aa); NP_346654.1|NC_003030
                     from Clostridium acetobutylicum (830 aa);
                     NP_387888.1|NC_000964 from Bacillus subtilis (821 aa);
                     etc. Contains PS00018 EF-hand calcium-binding domain.
                     Protein product from Mb0006 detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb0006 found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3XU07"
                     /db_xref="InterPro:IPR002205"
                     /db_xref="InterPro:IPR005743"
                     /db_xref="InterPro:IPR006691"
                     /db_xref="InterPro:IPR013757"
                     /db_xref="InterPro:IPR013758"
                     /db_xref="InterPro:IPR013760"
                     /db_xref="InterPro:IPR035516"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XU07"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MTDTTLPPDD SLDRIEPVDI QQEMQRSYID YAMSVIVGRA LPEVRDGLKP VHRRVLYAMF
       61 DSGFRPDRSH AKSARSVAET MGNYHPHGDA SIYDTLVRMA QPWSLRYPLV DGQGNFGSPG
      121 NDPPAAMRYT EARLTPLAME MLREIDEETV DFIPNYDGRV QEPTVLPSRF PNLLANGSGG
      181 IAVGMATNIP PHNLRELADA VFWALENHDA DEEETLAAVM GRVKGPDFPT AGLIVGSQGT
      241 ADAYKTGRGS IRMRGVVEVE EDSRGRTSLV ITELPYQVNH DNFITSIAEQ VRDGKLAGIS
      301 NIEDQSSDRV GLRIVIEIKR DAVAKVVINN LYKHTQLQTS FGANMLAIVD GVPRTLRLDQ
      361 LIRYYVDHQL DVIVRRTTYR LRKANERAHI LRGLVKALDA LDEVIALIRA SETVDIARAG
      421 LIELLDIDEI QAQAILDMQL RRLAALERQR IIDDLAKIEA EIADLEDILA KPERQRGIVR
      481 DELAEIVDRH GDDRRTRIIA ADGDVSDEDL IAREDVVVTI TETGYAKRTK TDLYRSQKRG
      541 GKGVQGAGLK QDDIVAHFFV CSTHDLILFF TTQGRVYRAK AYDLPEASRT ARGQHVANLL
      601 AFQPEERIAQ VIQIRGYTDA PYLVLATRNG LVKKSKLTAF DSNRSGGIVA VNLRDNDELV
      661 GAVLCSADDD LLLVSANGQS IRFSATDEAL RPMGRATSGV QGMRFNIDDR LLSLNVVREG
      721 TYLLVATSGG YAKRTAIEEY PVQGRGGKGV LTVMYDRRRG RLVGALIVDD DSELYAVTSG
      781 GGVIRTAARQ VRKAGRQTKG VRLMNLGEGD TLLAIARNAE ESGDDNAVDA NGADQTGN
//