LOCUS       CAB5248131.1             252 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            THIAMIN BIOSYNTHESIS PROTEIN THIG (THIAZOLE BIOSYNTHESIS
            PROTEIN) protein.
ACCESSION   LT708304-430
PROTEIN_ID  CAB5248131.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="thiG"
                     /locus_tag="BQ2027_MB0425"
                     /note="Mb0425, thiG, len: 252 aa. Equivalent to Rv0417,
                     len: 252 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.6% identity in 252 aa overlap). Probable thiG, thiamin
                     biosynthesis protein, equivalent to
                     AL035159|MLCB1450_20|T44741|THIG probable thiamin
                     biosynthesis protein from Mycobacterium leprae (261 aa),
                     FASTA scores: opt: 1380, E(): 0, (86.8% identity in 250 aa
                     overlap). Also highly similar to others e.g.
                     SCOEDB|SC6E10.03|T35490|THIG probable thiazole
                     biosynthesis protein from Streptomyces coelicolor (264
                     aa); F82761|9105679|AAF83593.1|AE003919_4|XF0783|THIG
                     thiamin biosynthesis protein thiG from Xylella fastidiosa
                     (275 aa); P30139|THIG_ECOLI|7448315|B65206|409790|AAC43089
                     .1|U00006 THIG PROTEIN thiamin biosynthesis protein from
                     Escherichia coli strain K-12 (281 aa); etc. BELONGS TO THE
                     THIG FAMILY. Protein product from Mb0425 detected using
                     shotgun mass spectrometry and SWATH mass spectrometry.
                     Mb0425 found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
BEGIN
        1 MAESKLVIGD RSFASRLIMG TGGATNLAVL EQALIASGTE LTTVAIRRVD ADGGTGLLDL
       61 LNRLGITPLP NTAGCRSAAE AVLTAQLARE ALNTNWVKLE VIADERTLWP DAVELVRAAE
      121 QLVDDGFVVL PYTTDDPVLA RRLEDTGCAA VMPLGSPIGT GLGIANPHNI EMIVAGARVP
      181 VVLDAGIGTA SDAALAMELG CDAVLLASAV TRAADPPAMA AAMAAAVTAG YLARCAGRIP
      241 KRFWAQASSP AR
//