LOCUS       CAB5248016.1             210 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR/ACRR-
            FAMILY) protein.
ACCESSION   LT708304-315
PROTEIN_ID  CAB5248016.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0310"
                     /note="Mb0310, -, len: 210 aa. Equivalent to Rv0302, len:
                     210 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.5% identity in 210 aa overlap). Probable transcription
                     regulatory protein, TetR family, with its N-terminus
                     similar to N-terminus of several repressors and regulatory
                     proteins of TetR/AcrR family e.g. ACRR_ECOLI|P34000
                     potential acraB operon repressor from Escherichia coli
                     (215 aa), FASTA scores: opt: 172, E(): 3.1e-05, (22.7%
                     identity in 194 aa overlap). Also similar in N-terminus to
                     N-terminus of MTCY07A7.24 hypothetical regulator from
                     Mycobacterium tuberculosis FASTA score: (38.7% identity in
                     62 aa overlap). Contains probable helix-turn helix motif
                     from aa 35-56 (Score 1728, +5.07 SD). Mb0310 found to be
                     expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
BEGIN
        1 MGVPAKKKQQ QGERSRESIL DATERLMATK GYAATSISDI RDACGLAPSS IYWHFGSKEG
       61 VLAAMMERGA QRFFAAIPTW DEAHGPVEQR SERQLTELVS LQSQHPDFLR LFYLLSMERS
      121 QDPVVAAVVR RVRNTAIARF RDSITHLLPS DIPPGKADLV VAELTAFAVA LSDGVYFAGH
      181 LEPDTTDVER MYRRLRQALE ALIPVLLEET
//