LOCUS       CAB5247963.1             159 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 HEAT
            SHOCK PROTEIN HSP (HEAT-STRESS-INDUCED RIBOSOME-BINDING
            PROTEIN A) protein.
ACCESSION   LT708304-262
PROTEIN_ID  CAB5247963.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="hsp"
                     /locus_tag="BQ2027_MB0257C"
                     /standard_name="hsp 20; hrpA; acr2"
                     /note="Mb0257c, hsp, len: 159 aa. Equivalent to Rv0251c,
                     len: 159 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 159 aa overlap). hsp (alternate gene
                     name: hsp20, hrpA, acr2), heat-stress-induced
                     ribosome-binding protein A (see citations below). Highly
                     similar to AAD39038.1|AF072875_1|AF072875 putative HSP20
                     from Mycobacterium smegmatis (145 aa), FASTA scores: opt:
                     479, E(): 2.3e-24, (59.9% identity in 157 aa overlap); and
                     similar to many bacterial and eukaryotic hsp proteins e.g.
                     P12811|HS2C_CHLRE CHLOROPLAST HEAT SHOCK 22KD PROTEIN from
                     CHLAMYDOMONAS REINHARDTII (157 aa), FASTA scores: opt:
                     184, E(): 1.2e-05, (32.4% identity in 142 aa overlap).
                     Also similar to PCC6803 Spore protein sp21 from
                     Synechocystis sp. (146 aa), FASTA scores: opt: 213, E():
                     1.2e-07, (30.3 identity in 145 aa overlap). Also similar
                     to P30223|14KD_MYCTU 14 KDA ANTIGEN (16 KDA ANTIGEN) 19K
                     major membrane protein (HSP 16.3) from Mycobacterium
                     tuberculosis (144 aa). BELONG TO THE SMALL HEAT SHOCK
                     PROTEIN (HSP20) FAMILY. Protein product from Mb0257c
                     detected using shotgun mass spectrometry. Mb0257c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MNNLALWSRP VWDVEPWDRW LRDFFGPAAT TDWYRPVAGD FTPAAEIVKD GDDAVVRLEL
       61 PGIDVDKDVN VELDPGQPVS RLVIRGEHRD EHTQDAGDKD GRTLREIRYG SFRRSFRLPA
      121 HVTSEAIAAS YDAGVLTVRV AGAYKAPAET QAQRIAITK
//