LOCUS       CAB5247941.1             326 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            PHOSPHOTRIESTERASE PHP (PARATHION HYDROLASE) (PTE) (ARYLDIALKYLPHOSP
            HATASE) (PARAOXONASE) (A-ESTERASE) (ARYLTRIPHOSPHATASE)
            (PARAOXON HYDROLASE) protein.
ACCESSION   LT708304-240
PROTEIN_ID  CAB5247941.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="php"
                     /locus_tag="BQ2027_MB0235C"
                     /note="Mb0235c, php, len: 326 aa. Equivalent to Rv0230c,
                     len: 326 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.7% identity in 326 aa overlap). Probable php,
                     phosphotriesterase (EC 3.1.8.1), similar to others e.g.
                     AAK42653.1|AE006849 putative aryldialkylphosphatase
                     (phosphotriesterase) (paraoxonase) from Sulfolobus
                     solfataricus (314 aa); PHP_ECOLI|P45548 PHOSPHOTRIESTERASE
                     HOMOLOGY PROTEIN from Escherichia coli (292 aa), FASTA
                     scores: opt: 408, E(): 7.1e-20, (31.1% identity in 305 aa
                     overlap); OPD_FLASP|P16648 parathion hydrolase precursor
                     (365 aa), FASTA scores: opt: 319, E(): 5.1e-14, (34.5%
                     identity in 333 aa overlap); etc. BELONGS TO THE
                     PHOSPHOTRIESTERASE FAMILY. COFACTOR: CONTAINS 2 MOLES OF
                     ZINC PER SUBUNIT. Protein product from Mb0235c detected
                     using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb0235c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
BEGIN
        1 MPELNTARGP IDTADLGVTL MHEHVFIMTT EIAQNYPEAW GDEDKRVAGA IARLGELKAR
       61 GVDTIVDLTV IGLGRYIPRI ARVAAATELN IVVATGLYTY NDVPFYFHYL GPGAQLDGPE
      121 IMTDMFVRDI EHGIADTGIK AGILKCATDE PGLTPGVERV LRAVAQAHKR TGAPISTHTH
      181 AGLRRGLDQQ RIFAEEGVEL SRVVIGHCGD STDVGYLEEL IAAGSYLGMD RFGVDVISPF
      241 QDRVNIVARM CERGHADKMV LSHDACCYFD ALPEELVPVA MPNWHYLHIH NDVIPALKQH
      301 GVTDEQLHTM LVDNPRRIFE RQGGYQ
//