LOCUS       CAB5247927.1             388 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            ACYL-COA DEHYDROGENASE FADE3 protein.
ACCESSION   LT708304-226
PROTEIN_ID  CAB5247927.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="fadE3"
                     /locus_tag="BQ2027_MB0221C"
                     /note="Mb0221c, fadE3, len: 388 aa. Equivalent to Rv0215c,
                     len: 357 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 356 aa overlap). Probable fadE3,
                     acyl-dehydrogenase (EC 1.3.99.-), similar to many e.g.
                     ACDB_BACSU|P45857 acyl-CoA dehydrogenase from B. subtilis
                     (EC 1.3.99.-) (379 aa), FASTA scores: opt: 812, E(): 0,
                     (39.5% identity in 354 aa overlap).
                     REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a
                     29 bp insertion leads to a longer product compared to its
                     homolog in Mycobacterium tuberculosis strain H37Rv (388 aa
                     versus 357 aa). Protein product from Mb0221c detected
                     using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb0221c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
BEGIN
        1 MRNELNDDEA MLVATVRAFI DRDVKPTVRE VEHANSYPEA WIEQMKHIGI YGLAIDEQYG
       61 GSPVSMPCYV QVTQELARGW MSLAGAMGGH TVVAKLLTLF GTEEQRRTYL PPMASGELRA
      121 TMALTEPGGG SDLQNMSTTA LADGPEGSAG LLINGCKTWI SNARRSGLFA VLCKTDPNAT
      181 PRHQGMSIVL VEPGPGLTVS RDLPKLGYKG VESCELSFDN LRVPVSAILG GAMGQGFSQM
      241 MKGLETGRIQ VAARALGVAT AALEDSLAYA QQRESFGRPI WQHQAVGNYL ADMATKLTAA
      301 RQLTRYAAER YDSGQRCDME AGMAKLFASE VAMEIALNAV RIHGGYGYST EYDVERYFRD
      361 APLMILGEGT NEIQRNVIAG QLVARGGI
//