LOCUS       CAB5247867.1             475 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            NAD(P) TRANSHYDROGENASE (SUBUNIT BETA) PNTB [INTEGRAL
            MEMBRANE PROTEIN] (PYRIDINE NUCLEOTIDE TRANSHYDROGENASE
            SUBUNIT BETA) (NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE
            SUBUNIT BETA) protein.
ACCESSION   LT708304-166
PROTEIN_ID  CAB5247867.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="pntB"
                     /locus_tag="BQ2027_MB0162"
                     /note="Mb0162, pntB, len: 475 aa. Equivalent to Rv0157,
                     len: 475 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 475 aa overlap). Probable pntB,
                     pyridine nucleotide transhydrogenase (nicotinamide
                     nucleotide transhydrogenase) subunit beta (EC 1.6.1.1),
                     integral membrane protein, similar to others e.g. Q59763
                     PROTON-TRANSLOCATING NICOTINAMIDE NUCLEOTIDE
                     TRANSHYDROGENASE SUBUNIT BETA from HODOSPIRILLUM RUBRUM
                     (464 aa), FASTA scores: opt: 1344, E(): 0, (46.4% identity
                     in 472 aa overlap);
                     P07002|PNTB_ECOLI|P76890|PNTB|B1602|Z2597|ECS2308 NAD(P)
                     TRANSHYDROGENASE SUBUNIT BETA from Escherichia coli
                     strains K12 and O157:H7 (462 aa). Protein product from
                     Mb0162 detected using shotgun mass spectrometry and SWATH
                     mass spectrometry. Mb0162 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
BEGIN
        1 MNLHYLVEIL YIISFSLFIY GLMGLTGPKT AVRGNLIAAA GMTIAVAATL VMIRHTSQWP
       61 LIIAGLVVGV VLGVPPARLT KMTAMPQLVA FFNGVGGGTV ALIALSEFID TTGFSAFQHG
      121 ESPTVHIVVA SLFAAIIGSI SFWGSIVAFG KLQEIISGRP IGLGKAQQPI NLLLLAVAVA
      181 AAVVIGLHAH PGSGGVALWW MIGLLVAAGV LGLMVVLPIG GADMPVVISM LNAMTGLSAA
      241 AAGLALNNTA MIVAGMIVGA SGSILTNLMA KAMNRSIPAI VAGGFGGGGV APSGGGDDKH
      301 VKATSAADAA IQMAYANQVI VVPGYGLAVA QAQHAVKDLA TLLEDRGVPV KYAIHPVAGR
      361 MPGHMNVLLA EAEVDYDAMK DMDDINDEFA RTDVTIVIGA NDVTNPAARN ETSSPIYGMP
      421 ILNVDKSRSV IVLKRSMNSG FAGIDNPLFY ADGTTMLFGD AKKSVTEVSE ELKAL
//