LOCUS       CAB5247792.1             488 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            HYDROGENASE HYCQ protein.
ACCESSION   LT708304-91
PROTEIN_ID  CAB5247792.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="hycQ"
                     /locus_tag="BQ2027_MB0089"
                     /note="Mb0089, hycQ, len: 488 aa. Equivalent to Rv0086,
                     len: 488 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 488 aa overlap). Possible hycQ,
                     hydrogenase (EC 1.-.-.-), integral membrane protein,
                     weakly similar to P77437|HYFF_ECOLI HYDROGENASE-4
                     COMPONENT F from Escherichia coli (526 aa), FASTA scores:
                     opt: 948, E(): 0, (35.9% identity in 493 aa overlap); and
                     AAK06855.1|AF335723_1|AF335723 hydrogenase-4 component B
                     from Burkholderia pseudomallei (668 aa). Also similar to
                     d9087711 & NUOL_ECOLI|P33607 NADH dehydrogenase I chain L
                     from Escherichia coli (613 aa), FASTA scores: opt: 360,
                     E():3.2e-13, (27.9% identity in 488 aa overlap); and to
                     NUON_ECOLI|P33608 NADH dehydrogenase I chain N from
                     Escherichia coli (425 aa), FASTA scores: opt: 375, E():
                     3.9e-14, (25.0% identity in 432 aa overlap). Mb0089 found
                     to be expressed during exponential growth in Sauton's
                     minimal media by RNA-sequencing (TPM > 20)."
BEGIN
        1 MTGLLLAAIL APLAASIASL ITGWRRTTAT LTALSATTVL ACAVAMGFWM GSGAQFGLGG
       61 LLRADALTVV MLVVIGIVGT LATAASIGYI DTELAHGHID GRSARLYGVL TPAFLCATVL
      121 AVCANNIGVI WVAIEATTVI TAFLVGHRRT RTALEATWKY VVICSVGIAV AFLGTVLLYF
      181 AARDSGAAAA GALNLDILAE HAAGLDPGVA RLAGGLLLIG YGAKAGLFPF HTWLADAHSQ
      241 APAPVSALMS GVLLAVAFSV LIRLRPILDA VSGPAYLRNG LLVVGLATLL VAVLMLTVTG
      301 DVKRMLAYSS MEHMGLIAIA AAAGTTLAIA ALLLHVLAHG IGKTVLFLAG GQLQAAHDST
      361 AIADITGVMR RSRLIGVSFA VGLIVLLGLP PFAMFASELA IARSLANERL AWVLGAALLL
      421 IAIGFTALAR NSGRMLLGTP AAGAPAITVP ATAAAALMVG IVVSAALGIT AGPLADLLGI
      481 AASNVGLP
//