LOCUS       CAA45219.1              1616 aa    PRT              HUM 11-DEC-1996
DEFINITION  Homo sapiens DNA (cytosine-5-)-methyltransferase protein.
ACCESSION   X63692-1
PROTEIN_ID  CAA45219.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1
  AUTHORS   Yen R.
  JOURNAL   Submitted (31-JAN-1992) to the INSDC. R. Yen, The Oncology Center,
            The Johns Hopkins Medical Inst, 424 N Bond Street, Baltimore MD
            21213, USA
  REMARK    Revised by [3]
REFERENCE   2  (bases 1 to 5194)
  AUTHORS   Yen R.W.C., Vertino P.M., Nelkin B.D., Yu J.J., Deiry W.E.,
            Cumaraswamy A., Lennon G.G., Trask B.J., Celano P., Baylin S.B.
  TITLE     Isolation and characterization of the cDNA encoding human DNA
            methyltransferase
  JOURNAL   Nucleic Acids Res. 20(9), 2287-2291(1992).
   PUBMED   1594447
REFERENCE   3  (bases 1 to 5434)
  AUTHORS   Yen R.
  JOURNAL   Submitted (23-OCT-1996) to the INSDC. R. Yen, The Oncology Center,
            The Johns Hopkins Medical Inst, 424 N Bond Street, Baltimore MD
            21213, USA
REFERENCE   5  (bases 1 to 5434)
  AUTHORS   Bestor T., Laudano A., Mattaliano R., Ingram V.
  TITLE     Cloning and sequencing of mammalian DNA methyltransferase
  JOURNAL   J. Mol. Biol. 203(4), 971-983(1988).
   PUBMED   3210246
REFERENCE   6  (bases 1 to 5434)
  AUTHORS   Yoder J.A., Yen R.C., Vertino P.M., Bestor T.H., Baylin S.B.
  TITLE     New 5' regions of the murine and human genes for DNA
            (cytosine-5)-methyltransferase
  JOURNAL   J Biol Chem 271(49), 31092-31097(1996).
   PUBMED   8940105
FEATURES             Qualifiers
     source          /db_xref="H-InvDB:HIT000322624"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /cell_line="TT cells"
                     /cell_type="medullary thyroid carcinoma"
                     /db_xref="taxon:9606"
     protein         /EC_number="2.1.1.37"
                     /db_xref="GOA:P26358"
                     /db_xref="H-InvDB:HIT000322624.13"
                     /db_xref="HGNC:HGNC:2976"
                     /db_xref="InterPro:IPR001025"
                     /db_xref="InterPro:IPR001525"
                     /db_xref="InterPro:IPR002857"
                     /db_xref="InterPro:IPR010506"
                     /db_xref="InterPro:IPR017198"
                     /db_xref="InterPro:IPR018117"
                     /db_xref="InterPro:IPR022702"
                     /db_xref="InterPro:IPR029063"
                     /db_xref="InterPro:IPR031303"
                     /db_xref="PDB:3EPZ"
                     /db_xref="PDB:3PTA"
                     /db_xref="PDB:3SWR"
                     /db_xref="PDB:4WXX"
                     /db_xref="PDB:4YOC"
                     /db_xref="PDB:4Z96"
                     /db_xref="PDB:4Z97"
                     /db_xref="PDB:5WVO"
                     /db_xref="PDB:5YDR"
                     /db_xref="UniProtKB/Swiss-Prot:P26358"
BEGIN
        1 MPARTAPARV PTLAVPAISL PDDVRRRLKD LERDSLTEKE CVKEKLNLLH EFLQTEIKNQ
       61 LCDLETKLRK EELSEEGYLA KVKSLLNKDL SLENGAHAYN REVNGRLENG NQARSEARRV
      121 GMADANSPPK PLSKPRTPRR SKSDGEAKPE PSPSPRITRK STRQTTITSH FAKGPAKRKP
      181 QEESERAKSD ESIKEEDKDQ DEKRRRVTSR ERVARPLPAE EPERAKSGTR TEKEEERDEK
      241 EEKRLRSQTK EPTPKQKLKE EPDREARAGV QADEDEDGDE KDEKKHRSQP KDLAAKRRPE
      301 EKEPEKVNPQ ISDEKDEDEK EEKRRKTTPK EPTEKKMARA KTVMNSKTHP PKCIQCGQYL
      361 DDPDLKYGQH PPDAVDEPQM LTNEKLSIFD ANESGFESYE ALPQHKLTCF SVYCKHGHLC
      421 PIDTGLIEKN IELFFSGSAK PIYDDDPSLE GGVNGKNLGP INEWWITGFD GGEKALIGFS
      481 TSFAEYILMD PSPEYAPIFG LMQEKIYISK IVVEFLQSNS DSTYEDLINK IETTVPPSGL
      541 NLNRFTEDSL LRHAQFVVEQ VESYDEAGDS DEQPIFLTPC MRDLIKLAGV TLGQRRAQAR
      601 RQTIRHSTRE KDRGPTKATT TKLVYQIFDT FFAEQIEKDD REDKENAFKR RRCGVCEVCQ
      661 QPECGKCKAC KDMVKFGGSG RSKQACQERR CPNMAMKEAD DDEEVDDNIP EMPSPKKMHQ
      721 GKKKKQNKNR ISWVGEAVKT DGKKSYYKKV CIDAETLEVG DCVSVIPDDS SKPLYLARVT
      781 ALWEDSSNGQ MFHAHWFCAG TDTVLGATSD PLELFLVDEC EDMQLSYIHS KVKVIYKAPS
      841 ENWAMEGGMD PESLLEGDDG KTYFYQLWYD QDYARFESPP KTQPTEDNKF KFCVSCARLA
      901 EMRQKEIPRV LEQLEDLDSR VLYYSATKNG ILYRVGDGVY LPPEAFTFNI KLSSPVKRPR
      961 KEPVDEDLYP EHYRKYSDYI KGSNLDAPEP YRIGRIKEIF CPKKSNGRPN ETDIKIRVNK
     1021 FYRPENTHKS TPASYHADIN LLYWSDEEAV VDFKAVQGRC TVEYGEDLPE CVQVYSMGGP
     1081 NRFYFLEAYN AKSKSFEDPP NHARSPGNKG KGKGKGKGKP KSQACEPSEP EIEIKLPKLR
     1141 TLDVFSGCGG LSEGFHQAGI SDTLWAIEMW DPAAQAFRLN NPGSTVFTED CNILLKLVMA
     1201 GETTNSRGQR LPQKGDVEML CGGPPCQGFS GMNRFNSRTY SKFKNSLVVS FLSYCDYYRP
     1261 RFFLLENVRN FVSFKRSMVL KLTLRCLVRM GYQCTFGVLQ AGQYGVAQTR RRAIILAAAP
     1321 GEKLPLFPEP LHVFAPRACQ LSVVVDDKKF VSNITRLSSG PFRTITVRDT MSDLPEVRNG
     1381 ASALEISYNG EPQSWFQRQL RGAQYQPILR DHICKDMSAL VAARMRHIPL APGSDWRDLP
     1441 NIEVRLSDGT MARKLRYTHH DRKNGRSSSG ALRGVCSCVE AGKACDPAAR QFNTLIPWCL
     1501 PHTGNRHNHW AGLYGRLEWD GFFSTTVTNP EPMGKQGRVL HPEQHRVVSV RECARSQGFP
     1561 DTYRLFGNIL DKHRQVGNAV PPPLAKAIGL EIKLCMLAKA RESASAKIKE EEAAKD
//