LOCUS BAC68653.1 4881 aa PRT BCT 07-OCT-2016 DEFINITION Streptomyces avermitilis MA-4680 = NBRC 14893 type I polyketide synthase AVES 4 protein. ACCESSION BA000030-950 PROTEIN_ID BAC68653.1 SOURCE Streptomyces avermitilis MA-4680 = NBRC 14893 ORGANISM Streptomyces avermitilis MA-4680 = NBRC 14893 Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces. REFERENCE 1 (bases 1 to 9025608) AUTHORS Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C., Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T., Kushida,N., Shiba,T., Sakaki,Y. and Hattori,M. TITLE Direct Submission JOURNAL Submitted (29-MAR-2002) to the DDBJ/EMBL/GenBank databases. Contact:S Omura Kitasato University, Kitasato Institute for Life Sciences; 1-15-1 Kitasato, Sagamihara, Kanagawa 228-8555, Japan URL :http://avermitilis.ls.kitasato-u.ac.jp/ REFERENCE 2 AUTHORS Ikeda,H., Ishikawa,J., Hanamoto,A., Shinose,M., Kikuchi,H., Shiba,T., Sakaki,Y., Hattori,M. and Omura,S. TITLE Complete Genome Sequence and Comparative Analysis of the Industrial Microorganism Streptomyces avermitilis JOURNAL Nat. Biotechnol. 21, 526-531 (2003) REFERENCE 3 AUTHORS Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C., Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T., Kikuchi,H., Shiba,T., Sakaki,Y. and Hattori,M. TITLE Genome sequence of an industrial microorganism Streptomyces avermitilis: Deducing the ability of producing secondary metabolites JOURNAL Proc. Natl. Acad. Sci. U.S.A. 98, 12215-12220 (2001) REFERENCE 4 AUTHORS Ikeda,H., Shin-ya,K. and Omura,S. TITLE Genome mining of the Streptomyces avermitilis genome and development of genome-minimized hosts for heterologous expression of biosynthetic gene clusters JOURNAL J. Ind. Microbiol. Biotechnol. 41, 233-250 (2014) COMMENT This work was done in collaboration with Haruo Ikeda(*1), Jun Ishikawa(*2), Akiharu Hanamoto(*3), Chigusa Takahashi(*3), Mayumi Shinose(*3), Hiroshi Horikawa(*4), Hidekazu Nakazawa(*4), Tomomi Osonoe(*4), Norihiro Kushida(*4), Hisashi Kikuchi(*4), Tadayoshi Shiba(*5), Yoshiyuki Sakaki(*6,*7), Masahira Hattori(*1,*7) and Satoshi Omura(*1,*3). Final finishing process and all annotation were done by H. Ikeda and J. Ishikawa. *1 Kitasato Institute for Life Sciences, Kitasato University *2 National Institute of Infectious Diseases *3 The Kitasato Institute *4 National Institute of Technology and Evaluation *5 School of Science, Kitasato University *6 Institute of Medical Science, University of Tokyo *7 RIKEN, Genomic Sciences Center All the annotated genes identified are available from following urls. http://avermitilis.ls.kitasato-u.ac.jp FEATURES Qualifiers source /db_xref="taxon:227882" /mol_type="genomic DNA" /note="This strain is also named as strain: ATCC 31267, NCIMB 12804 or NRRL 8165." /organism="Streptomyces avermitilis MA-4680 = NBRC 14893" /strain="MA-4680" protein /gene="aveA4" /locus_tag="SAVERM_943" /old_locus_tag="SAV_943" /transl_table=11 BEGIN 1 MANEEKLRDY LKRVTADLLN VRRRLQQIES GEQEPIAIVG MACRFPGGVE SAEDFWELIA 61 SGRDAVGEFP VDRGWDVEAF YDPEPGRAGS SYTRRGGFLE GAAEFDAGFF GISPREALAM 121 DPQQRLMLEV SWEALERAGI DPATLRGSRT GVFAGLMSQD YATRLLSVPD DLAGYLGNGN 181 AGSILSGRVA YTFGFEGPAV TVDTACSSSL VALHLACQSL RTGESSFALA GGVTVMSTPG 241 MFVEFSRQRG LSPDGRCKAY ASAADGTGMS EGVGILLLER LSEAERRGHR VLAVVRGSAV 301 NQDGASNGLT APNGPSQQRV IRQALACAGL SVADVDVVEG HGTGTTLGDP IEAQALLATY 361 GQRAGDTPVW LGSVKSNIGH AQAAAGVAGV IKMVMALRAG VLPRTLHVDE PSSQVDWSSG 421 SVRVLADEVE WPGVEGRLRR AGVSAFGVSG TNAHVILEEA SGGAGGGAGR LQELGPGVVS 481 GSGVVPWVVS ARSELALRGQ ARRLRGVVAV GGGADGVGVS PAGVGRALVS ERSVFEHRAV 541 VVAEDRDEFL HALDALAGGR PVPGVVEGRT TSGELAVLFA GQGTQRAGMG RELYEAYPVF 601 AQAIDEICAE ADTARTDPGA PGLRDVLFAP QDSPEGRLIE DTGFAQPALF AFEVALFRLL 661 ETWGLTPDYV LGHSVGELAA AHVAGMLCLA DAVALVVARG RLMQGLPSGG AMVAIEASED 721 EILPLPDEYA SRVAHAAVNG PRSIVLSGDE DAVLDLAQQW AARGRRTRRL RTSHAFHSPH 781 MDAMLGDFRR AAEQVTFSAP RIPVVSNVTG APLPAETMCT PDYWVEHARS TVRFADGISW 841 LQEQGVTTCL EIGPDGTLSA LAQDSLSAPA RAIPALRPDQ PEARSVMTAL AELFVAGTAV 901 EWAGVFEGTA REVGDGCGVE LPTYAFERER FWLDVEEGSA GGSGVSGMWG GPLWEAVECG 961 DAGVVASLLG VDEGASLGAV VSALGEWGRV RHEREVVDGW RYREVWRPVS GGGVGGLSGA 1021 WLVVSEGEAG PVDVVAEGLE RCGARVVRVE VEAGCVSREV LAGHLREAVD GEAVGGVVSL 1081 VGWGSGVVQA GVASVGLVQA LGDVGVGARL WCVTGGAVSV GGRDAVWGPA SGVVWGLGRV 1141 VGAEAPDRWG GLVDVPELVD ERVVDGLVGV LAGVGGGGES EFAVRSSGAF VRRLVRAPLE 1201 EAVAEREWRP RGTVLVTGGT GELGAHVARW MARRGAEHLL LVSRRGESAQ GVEELRADLM 1261 GLGARVSVVA CDAADREALA EVLRSAVPAE CPLGVVVHAA GVVDDGVLEG LSSERVTGVL 1321 RAKALAAWNL HELTRGADLS GFVVFSSAAA TFGPAGQGSY AAANAYVEAI VRHRRGEGLP 1381 GLAVAWGPWA GGGMAEGAVG QMRRRGLAAM TPETALVALG QALDHDETCV TVADIDWDRF 1441 TANSLPGSRL SPLISDIPEA RLARETTGLD TATASPDSFS ARLKAMDTAE QERALLDLVR 1501 TYAATVLGHS TPTAVRPERA FRDLGFVSVS AVELRNRLNA VTGLLLPTTL IFDYPTPSAL 1561 AGYLKEQLEE GAGGQRDIAP PVPASRVDVD EPIAIVGMAC RFPGGVESAE DLWELVASGR 1621 DAVGEFPVDR GWDVEAFYDP EPGRAGSSYT RRGGFLEGAA EFDAGFFGIS PREALAMDPQ 1681 QRLMLEVSWE ALERAGIDPA TLRGSTTGVF AGMCSQDYAD LVRRATEDLE GYAMTGLSSS 1741 VTSGRVAYTL GLEGPAVTVD TACSSSLVAL HLACQALRSG ECSLALAGGV TVMSTPGAFV 1801 EFSRQRGLSP DGRCKAYGSG ADGVGWAEGV GVLLVERLSE AERRGHRVLA VVRGSAVNQD 1861 GASNGLTAPN GPSQQRVIRQ ALACAGLSVA DVDVVEGHGT GTTLGDPIEA QALLATYGQG 1921 RSGERPVWLG SVKSNIGHAQ AAAGVAGVIK MVMALRAGVL PRTLHVDEPS SQVDWSSGSV 1981 RVLADEVEWP GVEGRLRRAG VSAFGVSGTN AHVILEEASG GADGGAGRLQ ELGPGVVSGS 2041 GVVPWVVSAR SELALRGQAR RLRGVVAVGG GADGVGVSPA GVGRALVSER SVFEHRAVVV 2101 AEDRDEFLHA LDALAEGAPT AGVVQGVAGP AADGKIAMLF GGQGTHWEGM AQELLGSSPV 2161 FAQQMSDCAQ ALEPYLDWSL LDVLRGAPDA PPLQRVDVVQ PVLFAVMVSL AALWRSYGVH 2221 PDAVAGHSQG EIAAAYVAGA LSLDDAARVT ALRSQALAAL AGQGAMASVG LPVEKLEPRL 2281 ATWGDRLVIA AVNGARSAVV SGEPEAVDAL VEELSHEDVP ARRLMVDWAS HSPQVEAIQG 2341 RLLELLAPIR ARTGDVPFYS TVTGERIDGT ELDADYWYRN LRQVVRFRDA TQALVRAGHT 2401 VFIEACPHPA VAVGVQETLD EMGDLDSLVV GSLRRGEGGL RRFLMSVAEL FVGGVAVEWS 2461 GVFGSVGRGV AGGCGVELPT YAFERERFWL DVEGAPRGSG VSGQWGGQLS EAVDTVRGGM 2521 LRDCLAGLDP AAQAETVLDL VLTHAAAVLG HGTADAVVPE RAFRDLGFDS LTAVELRNRL 2581 NTATGLRFPR TLVFDHPRPV ALAAHIHEQL SGGSPTTGTA LALALRAPAP RVDVDEPIAI 2641 VGMACRFPGG VESAEDFWEL IASGRDAVGE FPVDRGWDVE AFYDPEPGRA GTSYTRCGGF 2701 LQGAAEFDAG FFGISPREAL AMDPQQRLML EVSWEALERA GIDPATLHGS TTGVFAGVSQ 2761 QDYAELLRRG TQDHEGYALT GVSNSVVSGR LSYTFGFEGP AVTVDTACSS SLVALHLACQ 2821 ALRSGECSLA LAGGVTVMST PGAFVEFSRQ RGLSPDGRCK AYGSGADGVG WAEGVGVLLV 2881 ERLSEAERRG HRVLAVVRGS AVNQDGASNG LTAPNGPSQQ RVIRQALACA GLSVADVDVV 2941 EGHGTGTTLG DPIEAQALLA TYGQGRSGER PVWLGSVKSN IGHAQAAAGV AGVIKMVMAL 3001 NHELLPTSLH IDEPSPHIDW SSGGVRLLTE PVPWQQNGRP RRAGVSAFGV SGTNAHVIIE 3061 QAPVEAHVIS EPVPAEAHVI VEQAPVEAPH VVDATGPADL TEPQEEAAEP ECVADAVTEM 3121 SAEPECVADA MSEMSAECVA EAVSDKSAEP ECVADAMSDK PALLPIPWLL SAKSERALRG 3181 QARRLRQFAA RASDARPADV AHALAAQRSV FDHRAVVVAE DRDGFLQALD ALAEGRSADG 3241 LIEGSVGPRG GHSGRRRGKT AMLFAGQGTQ RVGMGRQLYA AHPAYADALD QVLAELDGHL 3301 DQPLRPLIHA SADLADVADA ADVLDRTRYA QPALFAVQVA LFRHLERLGV RADFVAGHSI 3361 GELAAAHVAG VLPLAAACRL VAARGRLMEQ LAPGGAMVAV RASEAEARQA LDGREARVSV 3421 AAVNGPASVV FSGAEDEVGN MADWFAERGR RVKRLRTGHA FHSPLMDPML EEFQQVAASL 3481 TYSEPAIPMV STLTGDIVAA GELSDPEYWV RQVRRTVRFG DAISRLHTDG VRTFMELGPD 3541 GTLSALAEEC LEATADSHPA DDDTGTPQEN LLIPLLRPDS PEPGTLLTGL ARLHTHGAAA 3601 VNWPAALPER DRARHLDLPT YAFDHHRYWV DTSAGHPGDL SAAGLGTAGH PLLGSAVALA 3661 ESQELLFTGR LSLRTHPWLA DHAIFGTVLL PGTAILELAV RAGDEVDCGT VEELTLRTPL 3721 VLPEQGSVIL QLSVGAPQGP QTPEEPERRT FALYAREDDG LSSSSAAATG TEWTCHATGV 3781 LTGTARPAEE HTQEPWPPAD AAPVDLDGWY EQLAGAGLGY GPVFQGLREV WRRGDEVFAV 3841 VTLPESTEGQ AADAARYALH PALLDAALHP VVLRHEGDAA ADGHGWLPFS WTGVTVAASG 3901 ASTLHVRLTV RTDEDAVGLL ATDASGRIVI SAGSLAFRPV SAEQLQAART GYHDHLFRIE 3961 WRPLHLPTTP ARTADWALIG PGARRTAAVL ERNGASWQAY PDPAALAEAL AAGAPAPGMV 4021 VISCEPDGAS APTDSALTDS ALTDSAPAGS APADSTALAD ATRQATTRVL ALLQEWVADE 4081 RLAACRLALL THGSVTATPD EPVSDLAHAA VWGLVRSVQT ENPDRFLLAD TDDTDASRNA 4141 LPLLAGEPQI ALRNGAVRIP RMTRVPVRQP QPSTTDADWD PEATVLITGG TGVLGRLVAR 4201 HLATAHGVRH LLLATRRGTA ADGAADLVAE LAGLGAEATV AACDIGDRAA VAALLDQVPA 4261 QHPLKAVIHT AGVVDDGILT SLTPERMEAV LHAKAFGAAH LHDLTRDAGL TTFTVFSSAA 4321 ASFGSPGQGN YTAANAFLDA LMQHRHTQAL PGRSLAWGLW GEADGMTRNL AGTDFARMAR 4381 GGLLPLSNAQ GLALLDTADR LGPFGDGLLL ATRLDAATLH AQATAGALPR ILHGLIRIPA 4441 RRSADHGIAT DTPATLRERL AGLTIPAQRT GLLLELVRTH AAAVLGHPTS AVTAADGALP 4501 DDLVPADTEF RDLGFDSLTA VELRNRINAV TGLRLPATLI FDQPSPAALA DHLATRLTAE 4561 AGTPDEPAPA AAAAGAGSAG SAETGQQRST GSEKQQTRGG TSTETVESLF WIGHDTRRIE 4621 ESMALLSAAS FFRPAFTDPS DIPEPTFVRL AQGEARAQGE ALARGETRPA LICLPTVAAV 4681 SSVYQYSRFA AGLNGHRDVW YVPAPGFLEG EPLPSGIGAV TRMFADAIVR FTDGAPFALA 4741 GHSAGGWFVY AVTSHLERLG VRPEAVVTMD AYLPDDGIAP VASALTSEIF DRVTQFVDVD 4801 YTRLVAMGGY FRIFSGWSPP DITTPALFLR GRDGEQMPPP WGVPHTVLDI QGNHFTMLEQ 4861 FADSTARHVD EWLTEIASVR R //