LOCUS       BAA23382.1              1012 aa    PRT              HUM 30-SEP-1998
DEFINITION  Homo sapiens klotho protein.
ACCESSION   AB005142-1
PROTEIN_ID  BAA23382.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5003)
  AUTHORS   Kuro-o,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-JUN-1997) to the DDBJ/EMBL/GenBank databases.
            Contact:Makoto Kuro-o
            National Institute of Neuroscience, NCNP, Division of Molecular
            Genetics; 4-1-1 Ogawahigashi, Kodaira, Tokyo 187, Japan
REFERENCE   2  
  AUTHORS   Kuro-o,M., Matsumura,Y., Aizawa,H., Kawaguchi,H., Suga,T.,
            Utsugi,T., Ohyama,Y., Kurabayashi,M., Kamane,T., Kume,E.,
            Iwasaki,H., Iida,A., Shiraki-Iida,T., Nishikawa,S., Nagai,R. and
            Nabeshima,Y.
  TITLE     Mutation of the mouse klotho gene leads to a syndrome resembling
            ageing
  JOURNAL   Nature 390, 45-51 (1997)
COMMENT     
FEATURES             Qualifiers
     source          /db_xref="H-InvDB:HIT000058047"
                     /db_xref="taxon:9606"
                     /mol_type="mRNA"
                     /organism="Homo sapiens"
                     /tissue_type="kidney"
     protein         /gene="klotho"
                     /transl_table=1
BEGIN
        1 MPASAPPRRP RPPPPSLSLL LVLLGLGGRR LRAEPGDGAQ TWARVSRPPA PEAAGLFQGT
       61 FPDGFLWAVG SAAYQTEGGW QQHGKGASIW DTFTHHPLAP PGDSRNASLP LGAPSPLQPA
      121 TGDVASDSYN NVFRDTEALR ELGVTHYRFS ISWARVLPNG SAGVPNREGL RYYRRLLERL
      181 RELGVQPVVT LYHWDLPQRL QDAYGGWANR ALADHFRDYA ELCFRHFGGQ VKYWITIDNP
      241 YVVAWHGYAT GRLAPGIRGS PRLGYLVAHN LLLAHAKVWH LYNTSFRPTQ GGQVSIALSS
      301 HWINPRRMTD HSIKECQKSL DFVLGWFAKP VFIDGDYPES MKNNLSSILP DFTESEKKFI
      361 KGTADFFALC FGPTLSFQLL DPHMKFRQLE SPNLRQLLSW IDLEFNHPQI FIVENGWFVS
      421 GTTKRDDAKY MYYLKKFIME TLKAIKLDGV DVIGYTAWSL MDGFEWHRGY SIRRGLFYVD
      481 FLSQDKMLLP KSSALFYQKL IEKNGFPPLP ENQPLEGTFP CDFAWGVVDN YIQVDTTLSQ
      541 FTDLNVYLWD VHHSKRLIKV DGVVTKKRKS YCVDFAAIQP QIALLQEMHV THFRFSLDWA
      601 LILPLGNQSQ VNHTILQYYR CMASELVRVN ITPVVALWQP MAPNQGLPRL LARQGAWENP
      661 YTALAFAEYA RLCFQELGHH VKLWITMNEP YTRNMTYSAG HNLLKAHALA WHVYNEKFRH
      721 AQNGKISIAL QADWIEPACP FSQKDKEVAE RVLEFDIGWL AEPIFGSGDY PWVMRDWLNQ
      781 RNNFLLPYFT EDEKKLIQGT FDFLALSHYT TILVDSEKED PIKYNDYLEV QEMTDITWLN
      841 SPSQVAVVPW GLRKVLNWLK FKYGDLPMYI ISNGIDDGLH AEDDQLRVYY MQNYINEALK
      901 AHILDGINLC GYFAYSFNDR TAPRFGLYRY AADQFEPKAS MKHYRKIIDS NGFPGPETLE
      961 RFCPEEFTVC TECSFFHTRK SLLAFIAFLF FASIISLSLI FYYSKKGRRS YK
//