LOCUS       BAA01068.1               291 aa    PRT              HUM 16-FEB-2008
DEFINITION  Homo sapiens Pit-1/GHF-1 protein.
ACCESSION   D10216-1
PROTEIN_ID  BAA01068.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1262)
  AUTHORS   Tatsumi,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-JUL-1991) to the DDBJ/EMBL/GenBank databases.
            Contact:Keita Tatsumi
            Osaka University Medical School, Department of Laboratory
            Medicine; Yamada-oka 2-2, Suita-shi, Osaka 565, Japan
REFERENCE   2  
  AUTHORS   Tatsumi,K., Notomi,T., Amino,N. and Miyai,K.
  TITLE     Nucleotide sequence of the complementary DNA for human Pit-1/GHF-1
  JOURNAL   Biochim. Biophys. Acta 1129, 231-234 (1992)
REFERENCE   3  
  AUTHORS   Tatsumi,K., Miyai,K., Notomi,T., Kaibe,K., Amino,N., Mizuno,Y. and
            Kohno,H.
  TITLE     Cretinism with combined hormone deficiency caused by a mutation in
            the PIT1 gene
  JOURNAL   Nat. Genet. 1, 56-58 (1992)
COMMENT     This mutation converts the 172nd codon for Arg(CGA) to a
            termination codon(TGA) and results in the defect of the entire
            POU- homeo region. As the patient homozygous for this mutation
            showed combined pituitary hormone deficiencies of
            thyrotropin(TSH), growhth hormone(GH) and prolaction(PRL), the
            function of the human PIT1 gene is related to the differentiation
            and/or proliferation of TSH, GH, PRL producing cells, and/or
            transcriptional activation of the TSH, GH, PRL genes.
FEATURES             Qualifiers
     source          /db_xref="H-InvDB:HIT000100419"
                     /db_xref="taxon:9606"
                     /mol_type="mRNA"
                     /organism="Homo sapiens"
                     /tissue_type="pituitary"
     protein         /function="pituitary-specific POU-domain DNA binding
                     factor"
                     /gene="pit1"
BEGIN
        1 MSCQAFTSAD TFIPLNSDAS ATLPLIMHHS AAECLPVSNH ATNVMSTATG LHYSVPSCHY
       61 GNQPSTYGVM AGSLTPCLYK FPDHTLSHGF PPIHQPLLAE DPTAADFKQE LRRKSKLVEE
      121 PIDMDSPEIR ELEKFANEFK VRRIKLGYTQ TNVGEALAAV HGSEFSQTTI CRFENLQLSF
      181 KNACKLKAIL SKWLEEAEQV GALYNEKVGA NERKRKRRTT ISIAAKDALE RHFGEQNKPS
      241 SQEIMRMAEE LNLEKEVVRV WFCNRRQREK RVKTSLNQSL FSISKEHLEC R
//