LOCUS       AJF01616.1              1209 aa    PRT              BCT 20-JUN-2017
DEFINITION  Mycobacterium tuberculosis H37RvSiena putative 5-oxoprolinase
            OplA (5-oxo-L-prolinase) (pyroglutamase) (5-OPASE) protein.
ACCESSION   CP007027-272
PROTEIN_ID  AJF01616.1
SOURCE      Mycobacterium tuberculosis H37RvSiena
  ORGANISM  Mycobacterium tuberculosis H37RvSiena
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1  (bases 1 to 4410911)
  AUTHORS   Santoro,F., Guerrini,V., Lazzeri,E., Iannelli,F. and Pozzi,G.
  TITLE     Genomic polymorphisms in a Laboratory Isolate of Mycobacterium
            tuberculosis Reference Strain H37Rv (ATCC27294)
  JOURNAL   New Microbiol. 40 (1), 62-69 (2017)
   PUBMED   27819398
REFERENCE   2  (bases 1 to 4410911)
  AUTHORS   Guerrini,V., Santoro,F. and Pozzi,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-DEC-2013) Medical Biotechnology, University of Siena,
            viale Bracci, Policlinico Le Scotte, Siena 53100, Italy
REFERENCE   3  (bases 1 to 4410911)
  AUTHORS   Guerrini,V., Santoro,F. and Pozzi,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-FEB-2015) Medical Biotechnology, University of Siena,
            viale Bracci, Policlinico Le Scotte, Siena 53100, Italy
  REMARK    Protein update by submitter
COMMENT     Annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (released 2013). Information about the Pipeline can be
            found here: http://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            
            Annotation modified by submitter.
            
            ##Assembly-Data-START##
            Assembly Method       :: Ray v. 2.3.1
            Coverage              :: 300
            Sequencing Technology :: Illumina
            ##Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Provider          :: NCBI
            Annotation Date              :: 12/30/2013 09:28:23
            Annotation Pipeline          :: NCBI Prokaryotic Genome Annotation
                                            Pipeline
            Annotation Method            :: Best-placed reference protein set;
                                            GeneMarkS+
            Annotation Software revision :: 2.3 (rev. 422554)
            Features Annotated           :: Gene; CDS; rRNA; tRNA; ncRNA;
                                            repeat_region
            Genes                        :: 4,146
            CDS                          :: 4,050
            Pseudo Genes                 :: 42
            CRISPR Arrays                :: 2
            rRNAs                        :: 3 (5S, 16S, 23S)
            tRNAs                        :: 45
            ncRNA                        :: 6
            Frameshifted Genes           :: 34
            ##Genome-Annotation-Data-END##
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis H37RvSiena"
                     /mol_type="genomic DNA"
                     /strain="H37RvSiena"
                     /db_xref="taxon:1437856"
     protein         /gene="oplA"
                     /locus_tag="Y980_0266c"
                     /experiment="EXISTENCE: identified in proteomics study"
                     /note="Rv0266c, (MTCY06A4.10c) Probable oplA,
                     5-oxoprolinase, highly similar to others or to
                     hypothetical proteins e.g. AAK24340.1|AE005906
                     hydantoinase/oxoprolinase from Caulobacter crescentus
                     (1196 aa); NP_103129.1|14022305|BAB48915.1|AP002997
                     5-oxoprolinase from Mesorhizobium loti (1210 aa);
                     CAC48426.1|AL603642 conserved hypothetical protein from
                     Sinorhizobium meliloti (1205 aa);
                     S77037|slr0697|1006579|BAA10729.1|D6400 hypothetical
                     protein from Synechocystis sp. strain PCC 6803 (1252 aa);
                     P97608|OPLA_RAT|T42756|11278797 5-oxoprolinase
                     (5-oxo-L-prolinase) (pyroglutamase) (5-OPASE) from Rattus
                     norvegicus (1288 aa); etc. Belongs to the oxoprolinase
                     family."
                     /transl_table=11
                     /db_xref="GOA:L0T352"
                     /db_xref="InterPro:IPR002821"
                     /db_xref="InterPro:IPR003692"
                     /db_xref="InterPro:IPR008040"
                     /db_xref="UniProtKB/TrEMBL:L0T352"
BEGIN
        1 MVGAGWHFWV DRGGTFTDVV ARRPDGRLLT HKLLSDNPAR YRDAAVAGIR ALLANGEAGT
       61 RVDAVRMGTT VATNALLERT GERTLLVITR GFGDALRIAY QNRPRIFDRR IVLPEMLYER
      121 VVEVDERVTA DGRVLRAPDL EALGEKMRQA HADGIRAVAV VCLHSYLYPG HEREIGTLAQ
      181 RIGFAQISLS SEVSPLMKLV PRGDTTVVDA YLSPVLRRYI NQVADQMRGV RLMFMQSNGG
      241 LAQAGHFRGK DAILSGPAGG IVGMVRMSAL AGFDHVIGFD MGGTSTDVSH YAGEYERVFT
      301 TQVAGVRLRA PMLDIHTVAA GGGSILHFDG SRYRVGPDSA GADPGPACYR GGGPLCVTDA
      361 NVMLGRIQPT HFPSVFGPSG DQPLDAGTVR RGFTDLAADI AARTGDDRSP EQVAEGYLRI
      421 AVANMANAVK KISVQKGHDV TRYALTTFGG AGGQHACAVA DALGIRTVLI PPMAGVLSAL
      481 GIGLADTTAM REQSVEIPLG PAAPQRLASV AESLERAARA ELLDEGVPGE RIRVVRRVHL
      541 RYEGTDTAIP VQLAEIETMA TAFESSHRAL YTFLLDRPLI AEAISVEATG LTDQPDLSQL
      601 GDQANDTTGS SETVRIYSNG LWRDAPLRRR EAMRPGDVLT GPAIIAEANA TTVVDDGWQA
      661 TMTETGHLLA QRVVTPPRPD AATRAGFEAG FEADPVLLEI FNNLFMSIAE QMGFRLEATA
      721 QSVNIRERLD FSCALFDPDG NLVANAPHIP VHLGSMGTTV KEVIRRRLSG MKPGDVYAVN
      781 DPYHGGTHLP DITVITPVFN TGGEDVLFFV ASRGHHAEIG GITPGSMPAD SREIHEEGVL
      841 FDNWLLAENG RFREAETRRL LTEAPFGSRN PDTNLADLRA QIAANQKGVD EVGKMIDHFG
      901 RDVVAAYMRH VQDNAEEAVR RVIDRLDNGA YRYRMDSGAT IAVRITVDRA ARSATIDFTG
      961 TSAQLDTNFN APTSVVNAAV LYVFRTLVAD DIPLNDGCLR PLRIVVPEGS MLAPTHPAAV
     1021 VAGNVETSQA ITGALFAALG VQAEGSGTMN NVTFGNERHQ YYETVGSGSG AGDGYHGASV
     1081 VQTHMTNSRL TDPEVLEWRY PVLLREFAVR QGSGGAGRWR GGDGAVRRLE FTEPMTVSTL
     1141 SGHRRVRPYG MAGGSPGELG RNRVERADGS TVELAGCGST HVEPGDTLVI ETPGGGGYGP
     1201 ASTSARRRR
//